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Chemical Constituents from Solenostemma argel and their Cholinesterase Inhibitory Activity

Demmak RG, Bordage S, Bensegueni A, Boutaghane N, Hennebelle T, Mokrani EH, Sahpaz S

Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the...
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Isolation of Flavonoid Glycosides with Cholinesterase Inhibition Activity and Quantification from Stachys japonica

Nugroho A, Choi JS, Seong SH, Song BM, Park KS, Park HJ

The three flavone glycosides, 4′-O-methylisoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (1), isoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (3), and isoscutellarein 7-O-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (4) in addition to a flavonol glycoside, kaempferol 3-O-β-D-glucopyranoside (astragalin, 2), were isolated from Stachys japonica (Lamiaceae)....
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Regulation of Gastric Electrical and Mechanical Activity by Cholinesterases in Mice

Worth AA, Forrest AS, Peri LE, Ward SM, Hennig GW, Sanders KM

  • KMID: 2381252
  • J Neurogastroenterol Motil.
  • 2015 Apr;21(2):200-216.
  • doi: 10.5056/jnm14120
BACKGROUND/AIMS: Gastric peristalsis begins in the orad corpus and propagates to the pylorus. Directionality of peristalsis depends upon orderly generation and propagation of electrical slow waves and a frequency gradient...
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Comparison of Antiallodynic Effects between Intrathecal Cholinesterase Inhibitors and NMDA Antagonists on Two Neuropathic Pain Rat Models

Kang KN, Cho SJ, Hwang JH

BACKGOUND: Cholinesterase inhibitors and N-methyl-D-aspartate (NMDA) antagonists reduce the mechanical allodynia in neuropathic pain models. In this study our aim was to compare the antiallodynic effects between intrathecal cholinesterase inhibitors...
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Two Cases of Discontinuation Syndrome Following Cessation of Cholinesterase Inhibitors

Kwak YT

  • KMID: 2343089
  • J Korean Neurol Assoc.
  • 2004 Aug;22(4):386-388.
Discontinuation syndrome is a cluster of symptoms that appear when a patient terminates long-term medication. We report 2 patients with Alzheimer's disease who developed significant behavioral disturbances after the cessation...
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Regional Cerebral Blood Flow Changes in Alzheimer's Disease Patients Treated with Cholinesterase Inhibitors: A Preliminary Study using 99mTC-ECD SPECT

Park MY, Cho I

  • KMID: 2195071
  • J Korean Neurol Assoc.
  • 2003 Jun;21(3):255-260.
BACKGROUND: This study aimed to evaluate regional cerebral blood flow (rCBF) changes using 99mTC-ECD SPECT (Ethylene Cysteine Diethylester Single Photon Emission Computed Tomography) and contemporary clinical responses such as cognitive...
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Clinical Significance of Immediate Determination of Plasma Cholinesterase Level in Patients Presenting with Organophosphate Ingestion at the Time of Hospitalization

Chun BJ, Mun JM, Yoon HD, Heo T, Min YI

  • KMID: 1944456
  • J Korean Soc Emerg Med.
  • 2002 Mar;13(1):61-66.
PURPOSE: Plasma cholinesterase is a sensitive measure determining the severity of organophosphate intoxication. The author evaluated the usefulness of the plasma cholinesterase level as a prognostic indicator of the severity...
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Organophosphate Cholinesterase Inhibitor (Diisopropylfluorophosphate) Induces Acetylcholinesterase-mediated Nicotinic Receptor Facilitation

Sung JJ, Park KS, Lee KW

  • KMID: 2342859
  • J Korean Neurol Assoc.
  • 2000 Nov;18(6):735-740.
BACKGROUND: Cholinesterase inhibitors (ChEIs) which have been widely used clinically are known to have diverse actions on the neuromuscular synaptic transmissions, suggesting that inhibiting cholinesterase (ChE) might not be their...
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Pleural fluid to serum cholinesterase ratio for the differential diagnosis of transudates and exsudates

Cho H, Kim HI, Eum MS, Kwon HJ, Oh YL, Kim KS, Kim HJ

BACKGROUND: The criteria established by Light et al in 1972 have been used widely for the differential diagnosis of the pleural effusions in transudates and exsudates. However, in recent years,...
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The Effects of Ethanol on Cholinesterase Inactivation by Organophosphorous

Choi HC, Kim JH, Ha JH, Lee KY, Kim WJ, Woo HJ, Huh CU, Son SM, Chun EJ

  • KMID: 2320290
  • Yeungnam Univ J Med.
  • 1999 Dec;16(2):326-332.
BACKGROUND: In korea the agricultural community widely uses organophosphorous, and organophosphorous poisonings are increasing every year. We compared change in activity of acetylcholinesterase and pseudocholinesterase by organophosphorous and by the interaction...
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Influence of Various Muscle Relaxants on the Plasma Cholinesterase Activity

Kim SY, Lee JS, Yoo JS, Hwang KH, Kim SC, Park W, Kim EK, Choi SJ

BACKGROUND: The reduction in the plasma cholinesterase (PChE) level results in slow to hydrolysis of succinylcholine (SCC) and mivacurium (MIV). The factors altering the level of the normal enzyme in...
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Different Clinical Features of Organophosphate Insecticides Intoxication According to The Route of Administration: Disparity Between Clinical Severity And Plasma Cholinesterase Level

Oh BJ, Hwang SO, Lee KH, Hong ES, Lim JC, Kim H, Cho JH, Shin JS, Yoo KC

  • KMID: 1999027
  • J Korean Soc Emerg Med.
  • 1998 Mar;9(1):135-141.
BACKGROUND: Organophosphate insecticides poisoning is one of the most common toxicologic emergencies in Korea. There have been few reports of organophosphate intoxication via parenteral route, although many reports on organophosphate...
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Effect of Pancuronium, Vecuronium and Atracurium to the Plasma Cholinesterase Activity

Kim SY, Lee JS, Shim SH, Kim SI, Kim SC, Park W

BACKGROUND: Succinylcholine is metabolized by plasma cholinesterase (PChE). When it was pretreated by small doses of nondepolarizing muscle relaxants in order to minimize the side effects, there are evidences to...
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Prolonged Apnea after Cesarean Section in Patient with Low Level of Plasma Cholinesterase Activity: A case report

Tae IS, Rhyu JH, Sim KH, Chun BD, Lee SW

Succinylcholine-induced prolonged neuromuscular blockade may occur in patients with either a low level of plasma cholinesterase activity or genotypically abnormal form of that enzyme. We experienced a case of succinylcholine-induced...
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Cholinesterase activity and Pestieide Compounds in Blood of Pestieide Sprayers

Shin DC, Lee SY, Chung SH, Won JU, Park JS, Park SJ

  • KMID: 2074956
  • Korean J Occup Environ Med.
  • 1994 Sep;6(2):402-410.
In order to ascertain the status of health damage among Korean farmers who spray pesticides regularly in summer, blood and urine samples were collected for 88 volunteers during July to...
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Effects of Multiple Exposures to Pesticides on Plasma Cholinesterase Activity and p-nitrophenol Excretion in Rats

Cha BS, Park JG, Park JK, Chang SJ

  • KMID: 2282600
  • Korean J Prev Med.
  • 1992 Jun;25(2):180-188.
The effects of multiple exposures to pesticides on plasma cholinesterase(ChE) activities and urinary p-nitrophenol excretion were evaluated in rats. Rats were received single dose i.p. with LD50/100(mg/kg) of organophosphorous(OP), organophosphorous-organochroline(OP-OC),...
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Effects of Neostigmine , Pyridostigmine and Edrophonium on Plasma Cholinesterase Activity and Train-of-four Response

Kim SC, Hwang KH, Kim SY

Effects of the anticholinesterase drugs on plasma cholinesterase activity, plasma albumin level and train-of-four response were investigated in 38 ASA class 1 or 2 adult patients undergoing elective surgery. Anesthesia...
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Plasma Cholinesterase Activity and Reaction of Succinylcholine in Late Pregnancy

Bae SC, Han CS, Kim SI, Kim SC, Kim SY

Plasma cholinesterase (ChE), an enzyme produced by the liver, rapidly hydrolizes succinylcholine. In the presence of low enzymatic activity, the rate of destruction of succinylcholine is diminished and it may...
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The Changes of Serum Cholinesterase Activity in Term-Pregnant: In the Cesarean Section Patients

Kwon JH, Kim KH, Lee DH, Suh JK, Yoo HK, Chon SU, Kim KS, Jun JH, Seung IS

The serum cholinesterase level is influenced by a variety of disease states, especially in pregnancy as is well established now, although the reasons for the fall in the enzyme in...
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Plasma Cholinesterase Activity in the Sprayer Occupationally Exposed to Organic Phosphate Pesticides

Suh DS

  • KMID: 2282163
  • Korean J Prev Med.
  • 1983 Oct;16(1):51-58.
This study was carried out to obtain the basic data for the preverition of chronic poisoning by organic phosphate pesticides. 6 sprayers who participated in the summer pest control programs...
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