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Chemical Constituents from Solenostemma argel and their Cholinesterase Inhibitory Activity

Demmak RG, Bordage S, Bensegueni A, Boutaghane N, Hennebelle T, Mokrani EH, Sahpaz S

Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the...
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Acetylcholinesterase activity in the brain of wild birds in Korea—2014 to 2016

Bang JH, Ku HO, Kang HG, Kim H, Kim S, Park SW, Kim YS, Jang I, Bae YC, Woo GH, Yi H

Acetylcholinesterase (AChE) activity level can be used as a diagnostic marker for anticholinesterase pesticide poisoning. In this study, we aimed to establish a baseline level of normal brain AChE activity...
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Comparison of scopolamine-induced cognitive impairment responses in three different ICR stocks

Yoon WB, Choi HJ, Kim JE, Park JW, Kang MJ, Bae SJ, Lee YJ, Choi YS, Kim KS, Jung YS, Cho JY, Hwang DY, Song HK

Cognitive impairment responses are important research topics in the study of degenerative brain diseases as well as in understanding of human mental activities. To compare response to scopolamine (SPL)-induced cognitive...
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Pharmacotherapy for dementia

Youn H, Jeong HG

Dementia is a clinical syndrome characterized by a cluster of symptoms and signs that manifest as difficulties in cognitive functions such as memory, psychological and psychiatric changes, and impairments in...
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GABA-enriched fermented Laminaria japonica improves cognitive impairment and neuroplasticity in scopolamine- and ethanol-induced dementia model mice

Reid SN, Ryu JK, Kim Y, Jeon BH

BACKGROUND/OBJECTIVES: Fermented Laminaria japonica (FL), a type sea tangle used as a functional food ingredient, has been reported to possess cognitive improving properties that may aid in the treatment of...
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The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents

Shin CY, Kim HS, Cha KH, Won DH, Lee JY, Jang SW, Sohn UD

A previous study in humans demonstrated the sustained inhibitory effects of donepezil on acetylcholinesterase (AChE) activity; however, the effective concentration of donepezil in humans and animals is unclear. This study...
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Effect of Placenta-Derived Mesenchymal Stem Cells in a Dementia Rat Model via Microglial Mediation: a Comparison between Stem Cell Transplant Methods

Cho JS, Lee J, Jeong DU, Kim HW, Chang WS, Moon J, Chang JW

PURPOSE: Loss of cholinergic neurons in the hippocampus is a hallmark of many dementias. Administration of stem cells as a therapeutic intervention for patients is under active investigation, but the...
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Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model

Han SH, Kim SJ, Yun YW, Nam SY, Lee HJ, Lee BJ

This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJG0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-week-old male...
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Methidathion Poisoning

Kim KH, Kim SH, Her C

Although methidathion is an organophosphate insecticide, it is different from the other organophosphates in terms of toxicity. Because of its relatively high fat solubility, the apparent volume of methidathion distribution...
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A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii Roots

Park SY, Lee N, Lee S, Kim MJ, Chun W, Kim HP, Yang HJ, Lee HS, Kwon Y

Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2),...
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Sesquiterpenoids from the heartwood of Juniperu s chinensis

Jung HJ, Min BS, Jung HA, Choi JS

A new sesquiterpenoid, 11-hydroxy-valenc-1(10),3(4)-dien-2-one (3), two chemically synthesized but first isolate from nature, 3-oxocedran-8β-ol (1) and valenc-1(10),3(4),11(12)-trien-2-one (2) along with four known compounds, sugiol (4), (+)-nootkatone (5), 11-hydroxy-valenc-1(10)-en-2-one (6), and...
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Acetylcholinesterase Inhibitors from Angelica polymorpha Stem

Kwon Y, Kim HP, Kim MJ, Chun W

Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin...
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HPLC analysis of Phenolic Substances and Anti-Alzheimer's Activity of Korean Quercus Species

Nugroho A, Song BM, Seong SH, Choi JS, Choi J, Choi JY, Park HJ

This study aimed to establish the quantitative method to analyze the content of peroxynitrite-scavengers belonging to polyphenols in six Korean Quercus species (Quercus mongolica, Q. dentata, Q. acutissima, Q. alienta,...
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Evaluation of Antioxidant, Anti-cholinesterase, and Anti-inflammatory Effects of Culinary Mushroom Pleurotus pulmonarius

Nguyen TK, Im KH, Choi J, Shin PG, Lee TS

Culinary mushroom Pleurotus pulmonarius has been popular in Asian countries. In this study, the anti-oxidant, cholinesterase, and inflammation inhibitory activities of methanol extract (ME) of fruiting bodies of P. pulmonarius...
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The Usefulness of Calretinin Immunohistochemistry for Rectal Suction Biopsy to Diagnose Hirschsprung’s Disease

Jeong J, Kim SP, Jung E, Choi SO

PURPOSE: Hirschsprung’s disease (HD) is a congenital intestinal disorder with absence of ganglion cells in the intestinal muscle and submucosa. Diagnosis is based on histopathological study such as H&E, and...
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Chronic Nonmodulated Microwave Radiations in Mice Produce Anxiety-like and Depression-like Behaviours and Calcium- and NO-related Biochemical Changes in the Brain

Kumar M, Singh SP, Chaturvedi CM

The present study was aimed to investigate behavioural and biochemical effects of chronic exposure of amplitude modulated and non-modulated microwave radiation on laboratory mice. Chronic microwave exposures were executed with...
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Clinical Significance of Repetitive Compound Muscle Action Potentials in Patients with Myasthenia Gravis: A Predictor for Cholinergic Side Effects of Acetylcholinesterase Inhibitors

Lee HE, Kim YH, Kim SM, Shin HY

BACKGROUND AND PURPOSE: Acetylcholinesterase inhibitors (AChEIs) are widely used to treat myasthenia gravis (MG). Although AChEIs are usually tolerated well, some MG patients suffer from side effects. Furthermore, a small...
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Beneficial effect of diosgenin as a stimulator of NGF on the brain with neuronal damage induced by Aβ-42 accumulation and neurotoxicant injection

Koh EK, Yun WB, Kim JE, Song SH, Sung JE, Lee HA, Seo EJ, Jee SW, Bae CJ, Hwang DY

To investigate the beneficial effects of diosgenin (DG) on the multiple types of brain damage induced by Aβ-42 peptides and neurotoxicants, alterations in the specific aspects of brain functions were...
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Cognitive-Enhancing Effect of Dianthus superbus var. Longicalycinus on Scopolamine-Induced Memory Impairment in Mice

Weon JB, Jung YS, Ma CJ

Dianthus superbus (D. superbus) is a traditional crude drug used for the treatment of urethritis, carbuncles and carcinomas. The objective of this study was to confirm the cognitive enhancing effect...
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PET Radioligands for Imaging of Tau Pathology: Current Status

Choe YS, Lee KH

The incidence of Alzheimer's disease (AD), a progressive neurodegenerative disorder, continues to soar with the rapid growth of the elderly population, thus creating an enormous social and economic burden. Although...
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