- Continuous renal replacement therapy increased plasma cholinesterase activity in a case of acute organophosphate poisoning
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Kwon IH, Jeong J, Choi Y
- KMID: 2540156
- Acute Crit Care.
- 2022 Nov;37(4):669-671.
- doi: 10.4266/acc.2021.00780
Extracorporeal removal of organophosphate from blood has been proposed, but the efficacy of hemodialysis and hemoperfusion has not been established. We report a case of organophosphate poisoning in which continuous... -
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- Need for an Update for the Guideline for the Management of Mild Cognitive Impairment
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Kim M, Moon SY
- KMID: 2536274
- Dement Neurocogn Disord.
- 2022 Oct;21(4):107-116.
- doi: 10.12779/dnd.2022.21.4.107
Attention is being paid to diagnosis and treatment of mild cognitive impairment (MCI) because early diagnosis and preventive management can slow down the progression of Alzheimer’s disease. In particular, in... -
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- A Multinational, Multicenter, Randomized, Double-Blind, Active Comparator, Phase III Clinical Trial to Evaluate the Efficacy and Safety of Donepezil Transdermal Patch in Patients With Alzheimer’s Disease
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Han HJ, Park MY, Park KW, Park KH, Choi SH, Kim HJ, Yang DW, Ebenezer EGAM, Yang YH, Kewalram GM, Han SH, on Behalf the IPI-301 Study
- KMID: 2530857
- J Clin Neurol.
- 2022 Jul;18(4):428-436.
- doi: 10.3988/jcn.2022.18.4.428
Background and Purpose Oral administration of cholinesterase inhibitors is often associated with adverse gastrointestinal effects, and so developing an alternative administration route, such as transdermal, is urgently needed. The primary... -
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- Efficacy of Ulinastatin and Sulforaphane Alone or in Combination in Rat Model of Streptozotocin Diabetes Induced Vascular Dementia
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Sharma P, Kaushik P, Jain S, Sharma BM, Awasthi R, Kulkarni GT, Sharma B
- KMID: 2519555
- Clin Psychopharmacol Neurosci.
- 2021 Aug;19(3):470-489.
- doi: 10.9758/cpn.2021.19.3.470
Objective: Vascular Dementia (VaD), is associated with metabolic conditions. Diabetes is a major risk factor for the development of VaD. This study investigates the efficacy of ulinastatin (UTI) and sulforaphane... -
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- Butyrylcholinesterase Inhibitory Activity and GC-MS Analysis of Carica papaya Leaves
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Khaw KY, Yeou Chear NJ, Maran S, Yeong KY, Ong YS, Goh BH
- KMID: 2507474
- Nat Prod Sci.
- 2020 Jun;26(2):165-170.
- doi: 10.20307/nps.2020.26.2.165
Carica papaya is a medicinal and fruit plant owing biological activities including antioxidant, antiviral, antibacterial and anticancer. The present study aims to investigate the acetyl (AChE) and butyryl (BChE) cholinesterase... -
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- Clinical characteristics and cholinesterase levels in childrenwith carbofuran poisoning
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Yoon SA, Woo SI
- KMID: 2500272
- J Korean Soc Emerg Med.
- 2020 Apr;31(2):228-235.
Objective: Acute group poisoning caused by food ingestion occurred in an elementary school in Korea. We aimed to describe the clinical characteristics, emergency treatment, outcomes, and the cholinesterase level of children... -
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- Pyridostigmine in Pediatric Intestinal Pseudo-obstruction: Case Report of a 2-year Old Girl and Literature Review
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Di Nardo G, Viscogliosi F, Esposito F, Stanghellini V, Villa MP, Parisi P, Morlando A, Calò G, De Giorgio R
- KMID: 2460479
- J Neurogastroenterol Motil.
- 2019 Oct;25(4):508-514.
- doi: 10.5056/jnm19078
Pediatric chronic intestinal pseudo-obstruction is a rare disorder characterized by a severe impairment of gastrointestinal motility leading to intestinal obstruction symptoms in the absence of mechanical causes. The diagnosis is... -
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- Chemical Constituents from Solenostemma argel and their Cholinesterase Inhibitory Activity
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Demmak RG, Bordage S, Bensegueni A, Boutaghane N, Hennebelle T, Mokrani EH, Sahpaz S
- KMID: 2452780
- Nat Prod Sci.
- 2019 Jun;25(2):115-121.
- doi: 10.20307/nps.2019.25.2.115
Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the... -
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- Isolation of Flavonoid Glycosides with Cholinesterase Inhibition Activity and Quantification from Stachys japonica
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Nugroho A, Choi JS, Seong SH, Song BM, Park KS, Park HJ
- KMID: 2432421
- Nat Prod Sci.
- 2018 Dec;24(4):259-265.
- doi: 10.20307/nps.2018.24.4.259
The three flavone glycosides, 4′-O-methylisoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (1), isoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (3), and isoscutellarein 7-O-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (4) in addition to a flavonol glycoside, kaempferol 3-O-β-D-glucopyranoside (astragalin, 2), were isolated from Stachys japonica (Lamiaceae).... -
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- Pharmacotherapy for dementia
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Youn H, Jeong HG
- KMID: 2429340
- J Korean Med Assoc.
- 2018 Dec;61(12):758-764.
- doi: 10.5124/jkma.2018.61.12.758
Dementia is a clinical syndrome characterized by a cluster of symptoms and signs that manifest as difficulties in cognitive functions such as memory, psychological and psychiatric changes, and impairments in... -
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- Relative Risk and Clinical Severity Assessment in Patients with Non-Oral Route Organophosphate Poisoning Compared with Oral Route Poisoning
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Jung WJ, Yu MH, Lee Y, Kim H, Cha YS, Park KH
- KMID: 2419733
- Yonsei Med J.
- 2018 Oct;59(8):982-988.
- doi: 10.3349/ymj.2018.59.8.982
PURPOSE: Organophosphates, commonly used in agricultural pesticides, pose high risks and incidences of poisoning. In the present study, we investigated the relative risk and clinical severity, including laboratory results, of... -
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- Garcinexanthone G, a Selective Butyrylcholinesterase Inhibitor from the Stem Bark of Garcinia atroviridis
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Khaw KY, Murugaiyah V, Khairuddean M, Tan WN
- KMID: 2416067
- Nat Prod Sci.
- 2018 Jun;24(2):88-92.
- doi: 10.20307/nps.2018.24.2.88
The present study was undertaken to investigate the isolated compounds from the stem bark of Garcinia atroviridis as potential cholinesterase inhibitors and the ligand-enzyme interactions of selected bioactive compounds in... -
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- A survey of current concepts and practices related to use of neuromuscular blockers with antagonists and neuromuscular monitoring among Korean anesthesiologists
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Choi S, Jung M, Kim KM, Lee S, Yang HS, Lee JS
- KMID: 2436055
- Anesth Pain Med.
- 2018 Jan;13(1):47-52.
- doi: 10.17085/apm.2018.13.1.47
BACKGROUND: The goal of this nationwide survey was to investigate the current concepts and practices of the use of neuromuscular blockers and their antagonists, and the availability and clinical practice... -
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- A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii Roots
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Park SY, Lee N, Lee S, Kim MJ, Chun W, Kim HP, Yang HJ, Lee HS, Kwon Y
- KMID: 2393803
- Nat Prod Sci.
- 2017 Sep;23(3):213-216.
- doi: 10.20307/nps.2017.23.3.213
Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2),... -
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- Improvement of Visuo-spatial Function Assessed by Raven’s Colored Progressive Matrices in Dementia with Lewy Bodies by Donepezil Treatment
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Yoshino Y, Mori T, Yoshida T, Toyota Y, Shimizu H, Iga JI, Nishitani , Ueno SI
- KMID: 2388270
- Clin Psychopharmacol Neurosci.
- 2017 Aug;15(3):243-247.
- doi: 10.9758/cpn.2017.15.3.243
OBJECTIVE: Donepezil is used to improve cognitive impairment of dementia with Lewy bodies (DLB). Visuo-spatial dysfunction is a well-known symptom of DLB. Non-verbal Raven’s Colored Progressive Matrices (RCPM) were used... -
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- Acetylcholinesterase Inhibitors from Angelica polymorpha Stem
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Kwon Y, Kim HP, Kim MJ, Chun W
- KMID: 2387058
- Nat Prod Sci.
- 2017 Jun;23(2):97-102.
- doi: 10.20307/nps.2017.23.2.97
Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin... -
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- Pneumatosis Cystoides Intestinales and Portomesenteric Venous Gas following Anticholinesterase Pesticide Poisoning
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Lee SH, Lee KW, Jung JH
- KMID: 2386867
- J Korean Soc Clin Toxicol.
- 2017 Jun;15(1):56-59.
- doi: 10.22537/jksct.2017.15.1.56
Pneumatosis cystoides intestinalis and portomesenteric venous gas are uncommon radiological findings, but are found commonly in cases of bowel ischemia, or as a result of various non-ischemic conditions. A 72-year-old... -
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- Evaluation of Antioxidant, Anti-cholinesterase, and Anti-inflammatory Effects of Culinary Mushroom Pleurotus pulmonarius
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Nguyen TK, Im KH, Choi J, Shin PG, Lee TS
- KMID: 2366454
- Mycobiology.
- 2016 Dec;44(4):291-301.
- doi: 10.5941/MYCO.2016.44.4.291
Culinary mushroom Pleurotus pulmonarius has been popular in Asian countries. In this study, the anti-oxidant, cholinesterase, and inflammation inhibitory activities of methanol extract (ME) of fruiting bodies of P. pulmonarius... -
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- Clinical Significance of Repetitive Compound Muscle Action Potentials in Patients with Myasthenia Gravis: A Predictor for Cholinergic Side Effects of Acetylcholinesterase Inhibitors
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Lee HE, Kim YH, Kim SM, Shin HY
- KMID: 2385114
- J Clin Neurol.
- 2016 Oct;12(4):482-488.
- doi: 10.3988/jcn.2016.12.4.482
BACKGROUND AND PURPOSE: Acetylcholinesterase inhibitors (AChEIs) are widely used to treat myasthenia gravis (MG). Although AChEIs are usually tolerated well, some MG patients suffer from side effects. Furthermore, a small... -
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- Clinical Predictors for Mild Cognitive Impairment Progression in a Korean Cohort
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Shim YS, Yang DW, Yoon B, Lee Y, Hong CH, Seo SW, Yoon SJ, Jeong JH, Park MH, Choi SH, Kim SY
- KMID: 2442848
- Dement Neurocogn Disord.
- 2016 Sep;15(3):68-74.
- doi: 10.12779/dnd.2016.15.3.68
BACKGROUND AND PURPOSE: Patients with mild cognitive impairment (MCI) and their caregivers are concerned with the likelihood and time course of progression to dementia. This study was performed to identify... -
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