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Continuous renal replacement therapy increased plasma cholinesterase activity in a case of acute organophosphate poisoning

Kwon IH, Jeong J, Choi Y

Extracorporeal removal of organophosphate from blood has been proposed, but the efficacy of hemodialysis and hemoperfusion has not been established. We report a case of organophosphate poisoning in which continuous...
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Need for an Update for the Guideline for the Management of Mild Cognitive Impairment

Kim M, Moon SY

Attention is being paid to diagnosis and treatment of mild cognitive impairment (MCI) because early diagnosis and preventive management can slow down the progression of Alzheimer’s disease. In particular, in...
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A Multinational, Multicenter, Randomized, Double-Blind, Active Comparator, Phase III Clinical Trial to Evaluate the Efficacy and Safety of Donepezil Transdermal Patch in Patients With Alzheimer’s Disease

Han HJ, Park MY, Park KW, Park KH, Choi SH, Kim HJ, Yang DW, Ebenezer EGAM, Yang YH, Kewalram GM, Han SH, on Behalf the IPI-301 Study

Background and Purpose Oral administration of cholinesterase inhibitors is often associated with adverse gastrointestinal effects, and so developing an alternative administration route, such as transdermal, is urgently needed. The primary...
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Efficacy of Ulinastatin and Sulforaphane Alone or in Combination in Rat Model of Streptozotocin Diabetes Induced Vascular Dementia

Sharma P, Kaushik P, Jain S, Sharma BM, Awasthi R, Kulkarni GT, Sharma B

Objective: Vascular Dementia (VaD), is associated with metabolic conditions. Diabetes is a major risk factor for the development of VaD. This study investigates the efficacy of ulinastatin (UTI) and sulforaphane...
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Butyrylcholinesterase Inhibitory Activity and GC-MS Analysis of Carica papaya Leaves

Khaw KY, Yeou Chear NJ, Maran S, Yeong KY, Ong YS, Goh BH

Carica papaya is a medicinal and fruit plant owing biological activities including antioxidant, antiviral, antibacterial and anticancer. The present study aims to investigate the acetyl (AChE) and butyryl (BChE) cholinesterase...
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Clinical characteristics and cholinesterase levels in childrenwith carbofuran poisoning

Yoon SA, Woo SI

  • KMID: 2500272
  • J Korean Soc Emerg Med.
  • 2020 Apr;31(2):228-235.
Objective: Acute group poisoning caused by food ingestion occurred in an elementary school in Korea. We aimed to describe the clinical characteristics, emergency treatment, outcomes, and the cholinesterase level of children...
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Pyridostigmine in Pediatric Intestinal Pseudo-obstruction: Case Report of a 2-year Old Girl and Literature Review

Di Nardo G, Viscogliosi F, Esposito F, Stanghellini V, Villa MP, Parisi P, Morlando A, Calò G, De Giorgio R

  • KMID: 2460479
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):508-514.
  • doi: 10.5056/jnm19078
Pediatric chronic intestinal pseudo-obstruction is a rare disorder characterized by a severe impairment of gastrointestinal motility leading to intestinal obstruction symptoms in the absence of mechanical causes. The diagnosis is...
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Chemical Constituents from Solenostemma argel and their Cholinesterase Inhibitory Activity

Demmak RG, Bordage S, Bensegueni A, Boutaghane N, Hennebelle T, Mokrani EH, Sahpaz S

Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the...
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Isolation of Flavonoid Glycosides with Cholinesterase Inhibition Activity and Quantification from Stachys japonica

Nugroho A, Choi JS, Seong SH, Song BM, Park KS, Park HJ

The three flavone glycosides, 4′-O-methylisoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (1), isoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (3), and isoscutellarein 7-O-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (4) in addition to a flavonol glycoside, kaempferol 3-O-β-D-glucopyranoside (astragalin, 2), were isolated from Stachys japonica (Lamiaceae)....
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Pharmacotherapy for dementia

Youn H, Jeong HG

Dementia is a clinical syndrome characterized by a cluster of symptoms and signs that manifest as difficulties in cognitive functions such as memory, psychological and psychiatric changes, and impairments in...
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Relative Risk and Clinical Severity Assessment in Patients with Non-Oral Route Organophosphate Poisoning Compared with Oral Route Poisoning

Jung WJ, Yu MH, Lee Y, Kim H, Cha YS, Park KH

PURPOSE: Organophosphates, commonly used in agricultural pesticides, pose high risks and incidences of poisoning. In the present study, we investigated the relative risk and clinical severity, including laboratory results, of...
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Garcinexanthone G, a Selective Butyrylcholinesterase Inhibitor from the Stem Bark of Garcinia atroviridis

Khaw KY, Murugaiyah V, Khairuddean M, Tan WN

The present study was undertaken to investigate the isolated compounds from the stem bark of Garcinia atroviridis as potential cholinesterase inhibitors and the ligand-enzyme interactions of selected bioactive compounds in...
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A survey of current concepts and practices related to use of neuromuscular blockers with antagonists and neuromuscular monitoring among Korean anesthesiologists

Choi S, Jung M, Kim KM, Lee S, Yang HS, Lee JS

BACKGROUND: The goal of this nationwide survey was to investigate the current concepts and practices of the use of neuromuscular blockers and their antagonists, and the availability and clinical practice...
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A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii Roots

Park SY, Lee N, Lee S, Kim MJ, Chun W, Kim HP, Yang HJ, Lee HS, Kwon Y

Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2),...
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Improvement of Visuo-spatial Function Assessed by Raven’s Colored Progressive Matrices in Dementia with Lewy Bodies by Donepezil Treatment

Yoshino Y, Mori T, Yoshida T, Toyota Y, Shimizu H, Iga JI, Nishitani , Ueno SI

OBJECTIVE: Donepezil is used to improve cognitive impairment of dementia with Lewy bodies (DLB). Visuo-spatial dysfunction is a well-known symptom of DLB. Non-verbal Raven’s Colored Progressive Matrices (RCPM) were used...
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Acetylcholinesterase Inhibitors from Angelica polymorpha Stem

Kwon Y, Kim HP, Kim MJ, Chun W

Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin...
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Pneumatosis Cystoides Intestinales and Portomesenteric Venous Gas following Anticholinesterase Pesticide Poisoning

Lee SH, Lee KW, Jung JH

Pneumatosis cystoides intestinalis and portomesenteric venous gas are uncommon radiological findings, but are found commonly in cases of bowel ischemia, or as a result of various non-ischemic conditions. A 72-year-old...
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Evaluation of Antioxidant, Anti-cholinesterase, and Anti-inflammatory Effects of Culinary Mushroom Pleurotus pulmonarius

Nguyen TK, Im KH, Choi J, Shin PG, Lee TS

Culinary mushroom Pleurotus pulmonarius has been popular in Asian countries. In this study, the anti-oxidant, cholinesterase, and inflammation inhibitory activities of methanol extract (ME) of fruiting bodies of P. pulmonarius...
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Clinical Significance of Repetitive Compound Muscle Action Potentials in Patients with Myasthenia Gravis: A Predictor for Cholinergic Side Effects of Acetylcholinesterase Inhibitors

Lee HE, Kim YH, Kim SM, Shin HY

BACKGROUND AND PURPOSE: Acetylcholinesterase inhibitors (AChEIs) are widely used to treat myasthenia gravis (MG). Although AChEIs are usually tolerated well, some MG patients suffer from side effects. Furthermore, a small...
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Clinical Predictors for Mild Cognitive Impairment Progression in a Korean Cohort

Shim YS, Yang DW, Yoon B, Lee Y, Hong CH, Seo SW, Yoon SJ, Jeong JH, Park MH, Choi SH, Kim SY

BACKGROUND AND PURPOSE: Patients with mild cognitive impairment (MCI) and their caregivers are concerned with the likelihood and time course of progression to dementia. This study was performed to identify...
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