Korean J Intern Med.  2019 Jan;34(1):202-209. 10.3904/kjim.2016.350.

Insulin resistance is an independent predictor of erectile dysfunction in patients with gout

Affiliations
  • 1Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea. rapark@catholic.ac.kr

Abstract

BACKGROUND/AIMS
Gout is associated with metabolic disorders that are important risk factors for cardiovascular disease and erectile dysfunction (ED). We aimed to identify independent predictors of ED in patients with gout.
METHODS
From August 2014 to August 2015, male outpatients who were being treated for gout in our rheumatology clinic and healthy males without any history of inflammatory disease (control group) were studied. ED was assessed in participants using the five-item version of the International Index of Erectile Function questionnaire. Insulin resistance (IR) was estimated using the homeostatic model assessment (HOMA-IR). Logistic regression analysis was performed to determine the effect of variables on ED risk in all of the study subjects and in patients with gout.
RESULTS
We analyzed 80 patients with gout and 70 healthy controls. The median age of patients with gout was 52 years and median disease duration was 120 months. Gout patients were more likely to have ED than controls (55.3% vs. 41.4%, p < 0.047). After adjustment for confounding factors, only HOMA-IR was significantly associated with ED (odds ratio [OR], 1.82; 95% confidence interval [CI], 1.05 to 3.15). Gout patients with ED were more likely to be older (p < 0.001), have higher HOMA-IR (p = 0.048), and have lower glomerular filtration rate (p = 0.038) than those without ED. Multivariate logistic regression analysis showed that HOMA-IR was an independent predictor for ED (OR, 1.62; 95% CI, 1.03 to 2.82) in gout patients.
CONCLUSIONS
IR is an independent predictor of ED in patients with gout.

Keyword

Arthritis, gouty; Erectile dysfunction; Insulin resistance

MeSH Terms

Arthritis, Gouty
Cardiovascular Diseases
Erectile Dysfunction*
Glomerular Filtration Rate
Gout*
Humans
Insulin Resistance*
Insulin*
Logistic Models
Male
Outpatients
Rheumatology
Risk Factors
Insulin
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