Korean J Pancreas Biliary Tract.  2016 Oct;21(4):202-208. 10.15279/kpba.2016.21.4.202.

Endoscopic Ultrasonography-Guided Ethanol Injection for a Pancreatic Neuroendocrine Tumor with Multiple Endocrine Neoplasia Type 1

  • 1Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sklee@amc.seoul.kr


Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited disorder caused by mutations in the MEN1 gene on chromosome 1. Clinical diagnostic criteria for MEN1 include the presence of two or more endocrine tumors such as pituitary, parathyroid, and pancreatic islet tumors. Treatment is needed for tumors accompanied by symptoms or having malignant potential. Malignant neuroendocrine tumors (NETs) are the major cause of MEN1-related death, and pancreatic NETs account for 30-80% of MEN1 cases. Surgery is the mainstay curative treatment, and endoscopic intervention is a treatment option when patients are poor candidates for surgery. A 33-year old female patient with MEN1 was treated via endoscopic ultrasonography-guided ethanol injection for a pancreatic NET.


Multiple endocrine neoplasia type 1; Pancreas; Neuroendocrine tumors; Endosonography; Ethanol
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