J Korean Med Sci.
2019 May;34(20):e149. 10.3346/jkms.2019.34.e149.
Cytochrome C Oxidase Subunit 1, Internal Transcribed Spacer 1, Nicotinamide Adenine Dinucleotide Hydrogen Dehydrogenase Subunits 2 and 5 of Clonorchis sinensis Ancient DNA Retrieved from Joseon Dynasty Mummy Specimens
- Affiliations
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- 1Laboratory of Bioanthropology, Paleopathology and History of Diseases, Seoul National University College of Medicine, Seoul, Korea. cuteminjae@gmail.com
- 2Institute of Forensic Science, Seoul National University College of Medicine, Seoul, Korea.
- 3Department of Tropical Medicine and Parasitology, Seoul National University College of Medicine, Seoul, Korea.
- 4Institute of Parasitic Diseases, Korean Association of Health Promotion, Seoul, Korea.
- 5Department of Parasitology, Dankook University College of Medicine, Cheonan, Korea. bbbenji@naver.com
- KMID: 2447038
- DOI: http://doi.org/10.3346/jkms.2019.34.e149
Abstract
- We analyzed Clonorchis sinensis ancient DNA (aDNA) acquired from the specimens of the Joseon mummies. The target regions were cytochrome C oxidase subunit 1 (CO1), internal transcribed spacer 1 (ITS1), nicotinamide adenine dinucleotide hydrogen (NADH) dehydrogenase subunits 2 (NAD2) and 5 (NAD5). The sequences of C. sinensis aDNA was completely or almost identical to modern C. sinensis sequences in GenBank. We also found that ITS1, NAD2 and NAD5 could be good markers for molecular diagnosis between C. sinensis and the other trematode parasite species. The current result could improve our knowledge about genetic history of C. sinensis.
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