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‘Testosterone Boosting’ Supplements Composition and Claims Are not Supported by the Academic Literature

Clemesha C, Thaker H, Samplaski

PURPOSE: Men take testosterone (T) boosting supplements to naturally improve T levels. We evaluated the composition and advertised claims of “T boosting” supplements, and supporting published evidence. MATERIALS AND METHODS: Fifty...
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The effect of alpha-lipoic acid on expression of VCAM-1 in type 2 diabetic rat

Ismawati , Mukhyarjon , Asni E, Romus I

Macrovascular diabetes complications are generally caused by a process called atherosclerosis. Evidences suggest that to initiate atherosclerosis, oxidated low-density lipoprotein (oxLDL) has to promote the expression of adhesion molecule. Several...
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Cytochrome C Oxidase Subunit 1, Internal Transcribed Spacer 1, Nicotinamide Adenine Dinucleotide Hydrogen Dehydrogenase Subunits 2 and 5 of Clonorchis sinensis Ancient DNA Retrieved from Joseon Dynasty Mummy Specimens

Hong JH, Oh CS, Chai JY, Seo M, Shin DH

We analyzed Clonorchis sinensis ancient DNA (aDNA) acquired from the specimens of the Joseon mummies. The target regions were cytochrome C oxidase subunit 1 (CO1), internal transcribed spacer 1 (ITS1),...
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Splitomicin, a SIRT1 Inhibitor, Enhances Hematopoietic Differentiation of Mouse Embryonic Stem Cells

Park JA, Park S, Park WY, Han MK, Lee Y

BACKGROUND AND OBJECTIVES: Embryonic stem (ES) cells have pluripotent ability to differentiate into multiple tissue lineages. SIRT1 is a class III histone deacetylase which modulates chromatin remodeling, gene silencing, cell...
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Nicotinamide riboside regulates inflammation and mitochondrial markers in AML12 hepatocytes

Lee HJ, Yang SJ

BACKGROUND/OBJECTIVES: The NAD+ precursor nicotinamide riboside (NR) is a type of vitamin B3 found in cow's milk and yeast-containing food products such as beer. Recent studies suggested that NR prevents...
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Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter

Zhen AX, Piao MJ, Kang KA, Madushan Fernando PDS, Kang HK, Koh YS, Yi JM, Hyun JW

Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that...
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Tryptophan Metabolites in Irritable Bowel Syndrome: An Overnight Time-course Study

Burr RL, Gu H, Cain K, Djukovic D, Zhang X, Han C, Callan N, Raftery D, Heitkemper M

  • KMID: 2460485
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):551-562.
  • doi: 10.5056/jnm19042
BACKGROUND/AIMS: Patients with irritable bowel syndrome (IBS) often report poor sleep quality. Whether poor sleep is associated with tryptophan (Trp) metabolites is unknown. We compared serum Trp metabolites in women...
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Rejuvenating Aged Hematopoietic Stem Cells Through Improvement of Mitochondrial Function

Moon J, Kim HR, Shin MG

Mitochondria are the powerhouses of the cell as well as the primary site of hematopoiesis, which also occurs in the cytoplasm. Hematopoietic stem cells (HSCs) are characterized by a very...
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Relationship Between Diet and Tinnitus: Korea National Health and Nutrition Examination Survey

Lee DY, Kim YH

OBJECTIVES: This study aimed to analyze the association between nutritional intake and tinnitus prevalence by evaluating a large cross-sectional cohort. METHODS: Data from the Korea National Health and Nutrition Examination Survey...
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The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 diabetic rats

Safhi MM, Anwer T, Khan G, Siddiqui R, Moni Sivakumar S, Alam MF

The present study was carried out with the hypothesis that combination of canagliflozin and omega-3 fatty acid may have potential effect on insulin level, insulin resistance, cardiac biomarkers, inflammatory cytokines...
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Enhancement of Replication and Differentiation Potential of Human Bone Marrow Stem Cells by Nicotinamide Treatment

Ok JS, Song SB, Hwang ES

BACKGROUND AND OBJECTIVES: Therapies using mesenchymal stem cells (MSCs) generally require substantial expansion of cell populations. However, the replicative life span of MSCs is limited and their multipotency declines over...
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Novel Therapeutic Target of Non-alcoholic Fatty Liver Disease: Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 and Reactive Oxygen Species in Pro-inflammatory Macrophages

Eun HS

No abstract available.
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Down-Regulation of TGF-β Expression Sensitizes the Resistance of Hepatocellular Carcinoma Cells to Sorafenib

Kang D, Han Z, Oh GH, Joo Y, Choi HJ, Song JJ

PURPOSE: Sorafenib, a multikinase inhibitor, is the standard therapy for patients with advanced-stage hepatocellular carcinoma (HCC). However, resistance develops to the treatment, therefore, we tried to unravel the underlying mechanism...
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Early changes in retinal structure and BMP2 expression in the retina and crystalline lens of streptozotocin-induced diabetic pigs

Jeong JS, Lee WK, Moon YS, Kim NR

PURPOSE: This study aims to evaluate early changes in retinal structure and BMP2 expression in the retina and crystalline lens by comparing streptozotocin-induced diabetic pigs and normal control group pigs. METHODS:...
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NAMPT enzyme activity regulates catabolic gene expression in gingival fibroblasts during periodontitis

Park KH, Kim DK, Huh YH, Lee G, Lee SH, Hong Y, Kim SH, Kook MS, Koh JT, Chun JS, Lee SE, Ryu JH

Periodontal disease is one of the most prevalent chronic disorders worldwide. It is accompanied by inflammation of the gingiva and destruction of periodontal tissues, leading to alveolar bone loss. Here,...
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A comparative study of sorafenib and metronomic chemotherapy for Barcelona Clinic Liver Cancer-stage C hepatocellular carcinoma with poor liver function

Yang H, Woo HY, Lee SK, Han JW, Jang B, Nam HC, Lee HL, Lee SW, Song DS, Song MJ, Oh JS, Chun HJ, Jang JW, Lozada A, Bae SH, Choi JY, Yoon SK

BACKGROUND/AIMS: Metronomic chemotherapy (MET) is frequently administered in comparatively low doses as a continuous chemotherapeutic agent. The aim of this study was to evaluate the feasibility and overall survival (OS)...
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Effectiveness of Hair Care Products Containing Placental Growth Factor for the Treatment of Postpartum Telogen Effluvium

Byeon JY, Choi HJ, Park ES, Kim JY

BACKGROUND: Postpartum telogen effluvium refers to a phenomenon in which some hair in the growth phase progresses rapidly to the resting phase, which leads to excessive hair loss. This causes...
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Nicotinamide Reduces Amyloid Precursor Protein and Presenilin 1 in Brain Tissues of Amyloid Beta-Tail Vein Injected Mice

Kim EJ, Yang SJ

The purpose of this study is to investigate whether nicotinic acid (NA) and nicotinamide (NAM) reduce the Alzheimer disease (AD)-related gene expression in brain tissues of amyloid beta (Aβ)-injected mice....
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Inhibition of Nicotinamide Phosphoribosyltransferase Induces Apoptosis in Estrogen Receptor-Positive MCF-7 Breast Cancer Cells

Alaee M, Khaghani S, Behroozfar K, Hesari Z, Ghorbanhosseini SS, Nourbakhsh M

PURPOSE: Tumor cells have increased turnover of nicotinamide adenine dinucleotide (NAD⁺), the main coenzyme in processes including adenosine diphosphate-ribosylation, deacetylation, and calcium mobilization. NAD⁺ is predominantly synthesized in human cells...
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Chemical Constituents Identified from Fruit Body of Cordyceps bassiana and Their Anti-Inflammatory Activity

Suh W, Nam G, Yang WS, Sung GH, Shim SH, Cho JY

Cordyceps bassiana is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. This mushroom has recently demonstrated to have an ability to reduce 2,4-dinitrofluorobenzene-induced atopic...
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