Korean J Helicobacter Up Gastrointest Res.  2018 Sep;18(3):186-197. 10.7704/kjhugr.2018.18.3.186.

Predictive Factors for Improvement of Atrophic Gastritis and Intestinal Metaplasia: A Long-term Prospective Clinical Study

Affiliations
  • 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. nayoungkim49@empas.com
  • 2Department of Internal Medicine and Institute of Liver Research, Seoul National University College of Medicine, Seoul, Korea.
  • 3Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 4Division of Statistics in Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract

BACKGROUND/AIMS
To investigate the predictive factors for improvement of atrophic gastritis (AG) and intestinal metaplasia (IM).
MATERIALS AND METHODS
A total of 778 subjects were prospectively enrolled and followed up for 10 years. Histological analysis of AG and IM was performed by using the updated Sydney system. To find the predictive factors for reversibility of AG and IM, 24 factors including genetic polymorphisms and bacterial and environmental factors were analyzed.
RESULTS
In all subjects, the predictive factor by multivariate analysis for improvement of both antral and corpus AG was successful eradication. The predictive factors for improvement of antral IM were age and successful eradication. The predictive factor for improvement of corpus IM was successful eradication. In patients with Helicobacter pylori infection, age and cagA were predictive factors for improvement of AG and IM. In patients with H. pylori eradication, monthly income and cagA were predictive factors for improvement of AG and IM.
CONCLUSIONS
H. pylori eradication is an important predictive factor of regression of AG and IM and would be beneficial for the prevention of intestinal-type gastric cancer. Young age, high income, and cagA are additional predictive factors for improving AG and IM status. Thus, various factors affect the improvement of AG and IM.

Keyword

Atrophic gastritis; Helicobacter pylori; Intestinal metaplasia; Therapeutics

MeSH Terms

Clinical Study*
Gastritis, Atrophic*
Helicobacter pylori
Humans
Metaplasia*
Multivariate Analysis
Polymorphism, Genetic
Prospective Studies*
Stomach Neoplasms
Full Text Links
  • KJHUGR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error