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Autoimmune Pancreatitis and Immunoglobulin G4-related Sclerosing Cholangitis: Past, Present, and Future

Moon SH, Kim MH

new disease entity, has attracted considerable interest within the international gastroenterology community. The typical manifestations of AIP/IgG4-SC are obstructive jaundice and pancreatic enlargement in the elderly, which may mimic the...
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Esophageal Diverticulum

Shin CM

An esophageal diverticulum is rare and is usually asymptomatic, although this condition may cause dysphagia, regurgitation, chest pain, globus, halitosis, and aspiration pneumonia. Based on its location and the characteristic...
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Therapeutics for the treatment of coronavirus disease 2019 in children and adolescents

Choi SH, Choi JH, Yun KW

Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory illness in most children and adolescents, but a small proportion develop severe or critical illness. Although pediatric clinical trials for...
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Clinical Evaluation of Digital Therapeutics: Present and Future

Huh KY, Oh J, Lee S, Yu KS

Objectives: Digital therapeutics (DTx) are software-based therapeutic interventions based on clinical evidence. Randomized clinical trials (RCTs) are often the source of clinical evidence, similar to conventional drugs or medical devices....
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A Multidisciplinary approach to treat massive recurrent hematochezia from a jejunal Dieulafoy lesion: A case report

Huynh TM, Le QD, Luu MN, Nguyen TTH, Bui QN, Tuong Mai AP, Duc Tran TH, Tran HM, Minh Vo CH, Quach DT

Jejunal Dieulafoy lesion (DL) is an exceedingly rare, life-threatening cause of gastrointestinal bleeding. Due to its rarity, intermittent bleeding symptoms that often necessitate prompt clinical intervention, variability in detection and...
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Endoscopic diagnosis and treatment of early colorectal cancer

Hong SW, Byeon JS

Early colorectal cancer refers to cancer in the colorectum that is confined to the mucosa or submucosa and does not invade the muscularis propria, irrespective of lymph node or distant...
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Current state and prospects of gout treatment in Korea

Park EH, Choi ST, Song JS

Effective management of gout includes the following: appropriate control of gout flares; lifestyle modifications; management of comorbidities; and long-term urate-lowering therapy (ULT) to prevent subsequent gout flares, structural joint damage,...
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Established and Emerging Therapies in Acute Spinal Cord Injury

Gadot R, Smith DN, Prablek M, Grochmal JK, Fuentes A, Ropper AE

Acute spinal cord injury (SCI) is devastating for patients and their caretakers and has an annual incidence of 20–50 per million people. Following initial assessment with appropriate physical examination and...
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Mechanism and efficacy of parathyroid hormone in osteoporosis

Kim SM

Background: Parathyroid hormone (PTH) and teriparatide, which is a PTH analog, are special options of osteoanabolic therapies for osteoporosis treatment. Their efficacy in improving the bone mineral density (BMD) and...
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Early Oxygen Requirement in Patients with Mild-to-Moderate COVID-19 Who Received Regdanvimab after DeltaVariant Outbreak

Lee CM, Park SW, Lee E

Background: Regdanvimab is a monoclonal antibody targeted against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and a treatment option for patients with mild-to moderate coronavirus disease 2019 (COVID-19). However, there...
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The classification, diagnosis, and treatment of rhinosinusitis

Joo YH

Background: Rhinosinusitis, one of the most common conditions encountered by clinicians, affects quality of life and reduces work productivity. Despite its high prevalence and economic burden, there are considerable differences...
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Therapeutic approach to non-curative resection after endoscopic treatment in early gastric cancer

Gong EJ, Bang CS

Background: Endoscopic resection is indicated for early or superficial gastrointestinal neoplasms with a negligible risk of lymph node metastasis. This procedure could preserve the organ while allowing en bloc resection...
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Endoscopic treatment for early gastric cancer

Ahn JY

Background: In Korea, the number of screening endoscopies to detect early stage gastric neoplasms has increased exponentially following the active implementation of the National Cancer Screening Program. Current Concepts: Endoscopic treatment,...
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Physiological Roles of Monomeric Amyloid-β and Implications for Alzheimer’s Disease Therapeutics

Jeong H, Shin H, Hong S, Kim Y

Alzheimer’s disease (AD) progressively inflicts impairment of synaptic functions with notable deposition of amyloid-β (Aβ) as senile plaques within the extracellular space of the brain. Accordingly, therapeutic directions for AD...
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Therapeutics in the Treatment of COVID-19 for Children and Adolescents

Choi SH, Choi JH, Yun KW

Coronavirus disease 2019 (COVID-19) presents as a mild-to-moderate respiratory illness in most children. However, a small proportion of children with COVID-19 develop severe or critical illnesses. Although pediatric clinical trials...
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KASL clinical practice guidelines for management of chronic hepatitis B

The Korean Association for the Study of the Liver (KASL)

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Risk factors associated with repeated epidural blood patches using autologous blood

Oh AR, Park J, Jeong JS, Lee JY, Choi JW, Kim H, Sim WS

Background: An epidural blood patch (EBP) is a procedure to treat intracranial hypotension that does not respond to conservative treatment. EBPs are commonly repeated when the symptoms persist. In this...
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Therapeutic Efficacy of Spironolactone for Central Serous Chorioretinopathy

Han JY, Kim YJ, Choi EY, Lee J, Lee JH, Kim M, Byeon SH, Kim SS, Lee CS

Purpose: To evaluate the therapeutic effects and safety of oral spironolactone (SPRL) in patients with central serous chorioretinopathy (CSC). Materials and Methods: The medical records and imaging data of patients diagnosed...
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Reimbursement of Digital Therapeutics: Future Perspectives in Korea

Ju JH, Sim B, Lee J, Lee JY

Digital health is rapidly growing worldwide and its area is expanding from wellness to treatment due to digital therapeutics (DTx). This study compared DTx in the Korean context with other...
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Overlap Between Constipation and Gastroesophageal Reflux Disease in Japan: Results From an Internet Survey

Ogasawara N, Funaki Y, Kasugai K, Ebi M, Tamura Y, Izawa S, Sasaki M

  • KMID: 2528044
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):291-302.
  • doi: 10.5056/jnm21065
Background/Aims Detailed evaluations of overlapping constipation and gastroesophageal reflux disease (GERD) have not been conducted in Japan. The REACTION-J2 study examined the overlap of these diseases in Japan. Methods This internet-based survey recruited...
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