J Korean Child Neurol Soc.
2018 Dec;26(4):284-287. 10.26815/jkcns.2018.26.4.284.
Tuberous Sclerosis Complex with Crohn's Disease
- Affiliations
-
- 1Department of Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.
- 2Department of Pediatrics, Chungnam National University Hospital, Daejeon, Korea. childlove@cnu.ac.kr
- 3Department of Pediatrics, Gyeongsang National University Changwon Hospital, Changwon, Korea.
- 4Department of Pediatrics & Medical Science, College of Medicine, Chungnam National University, Daejeon, Korea.
- KMID: 2437115
- DOI: http://doi.org/10.26815/jkcns.2018.26.4.284
Abstract
- Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutation of one of two genes, TSC1 (encoding hamartin, 9q34) and TSC2 (encoding tuberin, 16p13). It invades the central nervous system and various parts of the body, causing various symptoms. Crohn's disease (CD) is a chronic immune-mediated disease that has not been clearly elucidated. It is thought to be caused by an excessive immune response of the body to bacteria that normally exist in the digestive tract with genetic factors. No cases have been reported in which both of the above-mentioned diseases occurred simultaneously. We report a case of CD in a patient with TSC. A 12-year-old boy was brought to our hospital because of abdominal pain. Skin lesions were observed in the TSC. Fundus examination revealed a hamartoma in the right retina. Brain magnetic resonance imaging revealed a subendothelial giant cell astrocytoma (SEGA). On the basis of these findings, he was diagnosed as having TSC. Blood test results showed increased levels of inflammatory markers. On abdominal ultrasonography, his colon walls were observed to be thickened with increased vascularity of the proximal ascending colon, ileocecal valve, and terminal ileum. Colonoscopy revealed discontinuous ulcerations and inflammations of the ileum, IC valve, and cecum, similar to those found in CD. Everolimus was administered orally for the SEGA but was discontinued frequently owing to the exacerbation of CD. The possibility of CD should be kept in mind in patients with TSC considering to undergo treatment for SEGA.
Keyword
MeSH Terms
-
Abdominal Pain
Astrocytoma
Bacteria
Brain
Cecum
Central Nervous System
Child
Colon
Colon, Ascending
Colonoscopy
Crohn Disease*
Everolimus
Gastrointestinal Tract
Giant Cells
Hamartoma
Hematologic Tests
Humans
Ileocecal Valve
Ileum
Inflammation
Magnetic Resonance Imaging
Male
Retina
Skin
Tuberous Sclerosis*
Ulcer
Ultrasonography
Everolimus
