Ann Lab Med.  2018 Sep;38(5):431-439. 10.3343/alm.2018.38.5.431.

Postprandial Lipid Concentrations and Daytime Biological Variation of Lipids in a Healthy Chinese Population

• Yang D
• Cai Q
• Qi X
• Zhou Y

• KMID: 2434732
• DOI: http://doi.org/10.3343/alm.2018.38.5.431

Abstract

BACKGROUND
Several latest guidelines and consensus statements from Europe and the United States specify that there is no need for fasting prior to routine lipid tests. However, the latest Chinese guidelines still recommend fasting tests owing to a lack of local evidence. This study aimed to investigate postprandial lipid concentrations and daytime biological variation of lipids in a healthy Chinese population.
METHODS
Venous blood samples were collected from 41 ostensibly healthy Chinese volunteers at five time points during the day (06:30, 09:00, 12:00, 15:00, and 18:30). The same batch of reagents was used to determine lipid concentrations. A nested ANOVA was performed to calculate within-subject biological variation (CVI) and between-subject biological variation (CVG).
RESULTS
Postprandial concentrations of triglyceride were higher than fasting concentrations, with the maximum change occurring at 12:00 (0.5 hours after lunch, 0.21±0.65 mmol/L difference). The daytime biological variation of triglycerides was relatively high (CVI=25%, CVG=35.9%). The postprandial concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A1, and apolipoprotein B were mostly lower than the fasting concentrations, and their daytime biological variations were relatively low (CVI=2.4-4.4%, CVG=11.8-18.7%).
CONCLUSIONS
As most daytime lipid concentrations changed only slightly, non-fasting samples could be used for routine lipid tests. However, in cases of abnormal postprandial triglyceride concentrations, dietary factors and fasting time should be considered when interpreting the results.

Keyword

Biological variation; Postprandial lipids; Triglyceride; Fasting; Non-fasting

MeSH Terms

Apolipoprotein A-I
Apolipoproteins
Asian Continental Ancestry Group*
Cholesterol
Consensus
Europe
Fasting
Humans
Indicators and Reagents
Lipoproteins
Lunch
Triglycerides
United States
Volunteers
Apolipoprotein A-I
Apolipoproteins
Cholesterol
Indicators and Reagents
Lipoproteins
Triglycerides

Figure

• 

  Fig. 1 Changes in lipid concentrations of the 41 subjects at the five time points. (A) daytime changes in triglyceride, (B) daytime changes in total cholesterol, (C) daytime changes in LDL-C, (D) daytime changes in HDL-C, (E) daytime changes in apolipoprotein A1, and (F) daytime changes in apolipoprotein B. Subjects 1 to 21 were males and subjects 22 to 41 were females; each of the box plots presents the maximum value, upper quartile, median, lower quartile, and minimum value.Abbreviations: LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.

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