Intest Res.  2016 Apr;14(2):172-177. 10.5217/ir.2016.14.2.172.

Do we need colonoscopy verification in patients with fundic gland polyp?

• Lee HS
• Choi Y
• Jung JY
• Sung YJ
• Ahn DW
• Jeong JB
• Kim BG
• Lee KL
• Koh SJ
• Kim JW

• KMID: 2425290
• DOI: http://doi.org/10.5217/ir.2016.14.2.172

Abstract

BACKGROUND/AIMS
The aim of this study was to evaluate the prevalence of colorectal neoplasia in subjects with fundic gland polyps (FGPs) and the relationship between FGPs and colorectal neoplasia in Korea.
METHODS
We analyzed 128 consecutive patients with FPGs who underwent colonoscopy between January 2009 and December 2013. For each case, age- (±5 years) and sex-matched controls were identified from among patients with hyperplastic polyps, gastric neoplasms, and healthy controls. Clinical characteristics were reviewed from medical records, colonoscopic findings, pathologic findings, and computed tomography images. The outcome was evaluated by comparison of advanced colonic neoplasia detection rates.
RESULTS
Of the 128 patients, seven (5.1%) had colon cancers and seven (5.1%) had advanced adenomas. A case-control study revealed that the odds of detecting a colorectal cancer was 3.8 times greater in patients with FGPs than in the age- and sex-matched healthy controls (odds ratio [OR], 3.80; 95% confidence interval [CI], 1.09-13.24; P =0.04) and 4.1 times greater in patients with FGPs than in healthy controls over 50 years of age (OR, 4.10; 95% CI, 1.16-14.45; P =0.04). Among patients with FGPs over 50 years old, male sex (OR, 4.83; 95% CI, 1.23-18.94; P =0.02), and age (OR, 9.90; 95% CI, 1.21-81.08; P =0.03) were associated with an increased prevalence of advanced colorectal neoplasms.
CONCLUSIONS
The yield of colonoscopy in colorectal cancer patients with FGPs was substantially higher than that in average-risk subjects. Colonoscopy verification is warranted in patients with FGPs, especially in those 50 years of age or older.

Keyword

Fundic gland polyp; Colorectal neoplasia; Colonoscopy; Risk factors; Case-control studies

MeSH Terms

Adenoma
Case-Control Studies
Colon
Colonic Neoplasms
Colonoscopy*
Colorectal Neoplasms
Humans
Korea
Male
Medical Records
Polyps*
Prevalence
Risk Factors
Stomach Neoplasms

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