Korean J Gastroenterol.  2011 Jul;58(1):20-24. 10.4166/kjg.2011.58.1.20.

Gastric Fundic Gland Polyps and Their Relationship to Colorectal Neoplasia in Koreans: A 16-year Retrospective Study

• Hwang SM
• Kim BW
• Chae HS
• Lee BI
• Choi H
• Ji JS
• Choi KY
• Chung IS
• Maeng LS

• KMID: 1792810
• DOI: http://doi.org/10.4166/kjg.2011.58.1.20

Abstract

BACKGROUND/AIMS
There is an ongoing debate on the relationship between gastric fundic gland polyps and increased incidence of colorectal neoplasia in Caucasians. However, there was no report on the relationship between gastric fundic gland polyp and colorectal neoplasia in Korea. The aim of this study was to identify the characteristics of gastric fundic gland polyps and whether a relationship exists between fundic gland polyps and colorectal neoplasia in Korean population.
METHODS
Persons who underwent an esophagogastroduodenoscopy and colonoscopy from 1992 to 2007 at the Health Promotion Center of Incheon St. Mary's Hospital, The Catholic University of Korea were reviewed retrospectively. The relationship between gastric fundic gland polyps and colorectal neoplasia were analyzed.
RESULTS
Among 22,451 subjects, fundic gland polyps were found in 328 subjects (1.5%). Fundic gland polyps were more common in women than in men (odds ratio of 6.25; 95% CI of 4.68-8.34). The odds ratios for colorectal neoplasia in all subjects with gastric fundic gland polyps were 0.56 (95% CI of 0.33-0.95) and men who were 50 years of age or older had an odds ratio of 2.81 (95% CI of 1.03-7.66) as compared to the control group. However, age and sex-adjusted odds ratios for all gastric fundic gland polyps were 0.73 (95% CI of 0.42-1.26), for men 1.78 (95% CI of 0.80-3.98), and for women 0.37 (95% CI of 0.16-0.87).
CONCLUSIONS
Surveillance colonoscopy in patients with fundic gland polyps can be performed in the same manner as general population in Korea.

Keyword

Gastric fundus; Polyps; Colorectal neoplasms

MeSH Terms

Adult
Age Factors
Colorectal Neoplasms/*epidemiology/pathology
Endoscopy, Gastrointestinal
Female
Gastric Fundus/pathology
Humans
Male
Middle Aged
Odds Ratio
Polyps/*epidemiology/pathology
Republic of Korea
Retrospective Studies
Sex Factors

Figure

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  Fig. 1. A representative case of fundic gland polyp. (A) On esophagogastroduodenoscopy, a polypoid lesion was found on the fundus dome of the stomach. (B) On histopathology, cystically dilated and irregularly budded fundic glands were found (H&E stain, ×40).

Reference

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