Clin Psychopharmacol Neurosci.  2018 Feb;16(1):39-45. 10.9758/cpn.2018.16.1.39.

Thiol Disulfide Homeostasis in Schizophrenic Patients Using Atypical Antipsychotic Drugs

Affiliations
  • 1Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey. halefokan@gmail.com
  • 2Department of Psychiatry, Sivas Numune Hospital, Sivas, Turkey.
  • 3Department of Clinical Biochemistry, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.

Abstract

OBJECTIVE: Schizophrenia is a severe, debilitating mental disorder characterized by behavioral abnormalities. Although several studies have investigated the role of oxidative stress and the effects of antipsychotic drugs on oxidative markers in schizophrenia, adequate information is not available on these issues. The aim of this study is to determine the changes in oxidative status and thiol disulfide homeostasis in schizophrenic patients using atypical antipsychotic drugs.
METHODS
Thirteen schizophrenic patients using atypical antipsychotic drugs and 30 healthy controls were included this study. The concentrations of total oxidant status (TOS), total antioxidant status (TAS), native thiol, total thiol, and disulfide levels were determined in the study population.
RESULTS
The TAS (p=0.001), total thiol, and native thiol levels (p < 0.001) were higher in the patients compared to the controls, whereas the TOS and disulfide levels were lower in the patients than in the controls (p < 0.001).
CONCLUSION
These results may suggest that atypical antipsychotic drugs have a useful therapeutic effect by reducing oxidative stress via the inhibition of the formation of disulfide bonds. The study population number was one of the limitations of this study. Therefore, further studies are needed to establish the association between thiol disulfide homeostasis in schizophrenic patients using atypical antipsychotic drugs.

Keyword

Schizophrenia; Thiols; Disulfides; Antipsychotics
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