Korean J Pediatr.  2017 Dec;60(12):395-402. 10.3345/kjp.2017.60.12.395.

The influence of gonadotropin-releasing hormone agonists on anthropometric change in girls with central precocious puberty

• Yoon JW
• Park HA
• Lee J
• Kim JH

• KMID: 2398888
• DOI: http://doi.org/10.3345/kjp.2017.60.12.395

Abstract

PURPOSE
The potential effect of gonadotropin-releasing hormone agonist (GnRHa) treatment on the weight of girls with central precocious puberty (CPP) remains a controversy. We investigated anthropometric changes during and after GnRHa treatment among girls with CPP.
METHODS
This retrospective study evaluated data from 127 girls with CPP who received GnRHa treatment for ≥2 years. Height, weight, and body mass index (BMI) values were compared at the baseline (visit 1), after 1 year of GnRHa treatment (visit 2), the end of GnRHa treatment (visit 3), and 6-12 months after GnRHa discontinuation (visit 4).
RESULTS
The height z score for chronological age (CA) increased continuously between visit 1 and visit 4. No significant differences were observed in BMI z score for CA between visits 1 and 4. However, an increasing trend in the BMI z score for bone age (BA) was observed between visits 1 and 4. The numbers of participants who were of normal weight, overweight, and obese were 97, 22, and 8, respectively, at visit 1, compared to 100, 16, and 11, respectively, at visit 4 (P=0.48).
CONCLUSION
Among girls with CPP, the overall BMI z score for CA did not change significantly during or after GnRHa treatment discontinuation, regardless of their BMI status at visit 1. However, the BMI z score for BA showed an increasing trend during GnRHa treatment and a decreasing trend after discontinuation. Therefore, long-term follow-up of BMI changes among girls with CPP is required until they attain adult height.

Keyword

Precocious puberty,; Gonadotropin-releasing hormone agonist; Body mass index; Obesity

MeSH Terms

Adult
Body Mass Index
Female*
Follow-Up Studies
Gonadotropin-Releasing Hormone*
Humans
Obesity
Overweight
Puberty, Precocious*
Retrospective Studies
Gonadotropin-Releasing Hormone