Asia Pac Allergy.  2014 Jul;4(3):180-183. 10.5415/apallergy.2014.4.3.180.

Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen

• Pacharn P
• Siripipattanamongkol N
• Veskitkul
• Jirapongsananuruk O
• Visitsunthorn N
• Vichyanond P

• KMID: 2397097
• DOI: http://doi.org/10.5415/apallergy.2014.4.3.180

Abstract

We reported a successful oral immunotherapy (OIT) in 2 children with high wheat sensitivity (4 and 14 years old boys). Oral challenges indicated eliciting doses of 300 mg, and wheat flour of 30 mg. The OIT protocol includes 5 days of build-up phase in the hospital, intervening with 2 to 5 months of home maintenance phase. Patients could tolerate 45 g, and 60 g of wheat flour per day, respectively. We have demonstrated that OIT to a large amount of wheat in extremely sensitized patients could be achieved with a stepwise multi oral/maintenance regimen.

Keyword

Immunologic desensitization; Wheat allergy

MeSH Terms

Child
Desensitization, Immunologic
Flour
Humans
Immunotherapy*
Triticum
Wheat Hypersensitivity