J Korean Geriatr Psychiatry.  2017 Oct;21(2):87-91. 10.0000/jkgp.2017.21.2.87.

Association of Temporal Lobe Atrophy and Psychosis in Patients with Alzheimer's Disease

  • 1Department of Psychiatry, Pusan National University Hospital, Busan, Korea. psyleekr@naver.com
  • 2Department of Psychiatry, Pusan National University School of Medicine, Busan, Korea.
  • 3Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.


The purpose of this study is to investigate the difference on regional volume in temporal lobe between Alzheimer's disease patients with psychosis (AD+P) and Alzheimer's disease patients without psychosis (AD-P).
Altogether, 24 AD+P and 25 AD-P matched age, gender, and clinical dementia rating sum of box (CDR-SOB) were include from a Memory impairment clinics of Pusan National University Hospital in Korea. AD+P were diagnosed according to Jeste and Finkel's proposed diagnostic criteria for psychosis of Alzheimer's disease. Grey matter volume of temporal lobe was measured with 3-tesla magnetic resonance imaging and freesufer analysis. Analysis of variance was used to investigate the association between temporal lobe and AD+P after controlling age, gender, education years, CDR-SOB and total intracranial volume.
We found an association between AD+P and reduced grey matter volume in total temporal lobe as well as in specific temporal regions such as left middle temporal lobe, left inferior temporal lobe, both hippocampus and both fusiform.
Our findings suggest that AD+P are associated with reduced grey matter volume of temporal lobe.


Alzheimer's disease; Psychosis; Grey matter volume; Temporal lobe
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