Diabetes Metab J.  2017 Jun;41(3):205-212. 10.4093/dmj.2017.41.3.205.

The Effect of 12 Weeks Aerobic, Resistance, and Combined Exercises on Omentin-1 Levels and Insulin Resistance among Type 2 Diabetic Middle-Aged Women

• AminiLari
• Fararouei
• Amanat S
• Sinaei E
• Dianatinasab S
• AminiLari
• Daneshi N
• Dianatinasab M

• KMID: 2392495
• DOI: http://doi.org/10.4093/dmj.2017.41.3.205

Abstract

BACKGROUND
Recent studies have shown that omentin-1 derived from adipokines can affect physiological regulations and some metabolic dis-eases such as type 2 diabetes mellitus (T2DM).
METHODS
The purpose of this study was to examine the impact of 12 weeks of aerobic (cycle ergometer), resistance, and combined exercises on omentin-1 level, glucose and insulin resistance indices in overweight middle age women with T2DM. In this study, 60 overweight middle age diabetic women were selected using simple random sampling and they were assigned to three groups of aerobic exercise (n=12), resistant exercise (n=12) and combined exercise (n=13), and one control group (n=15). Exercises were done in a three times per week sessions for a total of 12 weeks. Blood samples were collected before each exercise session and 24 hours after of the last session.
RESULTS
Present study showed that fasting blood sugar decreased significantly in all intervention groups, while homeostasis model assessment of insulin resistance (HOMA-IR) decreased only in the aerobic and combined exercises groups. Furthermore, there was a significant increase in the omentin-1 level only in the combined exercise group.
CONCLUSION
Compared to aerobic and resistance exercises, 12 weeks of combined exercise was more efficient in improving HOMA-IR and increasing serum omentin-1 among women with T2DM.

Keyword

Diabetes mellitus, type 2; Exercise; Glucose; Insulin resistance; Omentin-1; Overweight women

MeSH Terms

Adipokines
Blood Glucose
Diabetes Mellitus, Type 2
Exercise*
Fasting
Female
Glucose
Homeostasis
Humans
Insulin Resistance*
Insulin*
Middle Aged
Overweight
Social Control, Formal
Adipokines
Blood Glucose
Glucose
Insulin

Figure

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  Fig. 1 Study flow diagram.

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  Fig. 2 Changes of (A) homeostasis model assessment of insulin resistance (HOMA-IR) and (B) serum omentin-1 before and after 12 weeks training intervention based on analysis of variance. RE, resistance exercise; AE, aerobic exercise; CE, combined exercise. aP<0.05 compare with control, bP<0.05 compare with resistance, cP<0.05 comparison with aerobic.

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