Clin Exp Vaccine Res.  2017 Jul;6(2):104-110. 10.7774/cevr.2017.6.2.104.

Animal models for dengue vaccine development and testing

• Na W
• Yeom M
• Choi IK
• Yook H
• Song D

• KMID: 2391570
• DOI: http://doi.org/10.7774/cevr.2017.6.2.104

Abstract

Dengue fever is a tropical endemic disease; however, because of climate change, it may become a problem in South Korea in the near future. Research on vaccines for dengue fever and outbreak preparedness are currently insufficient. In addition, because there are no appropriate animal models, controversial results from vaccine efficacy assessments and clinical trials have been reported. Therefore, to study the mechanism of dengue fever and test the immunogenicity of vaccines, an appropriate animal model is urgently needed. In addition to mouse models, more suitable models using animals that can be humanized will need to be constructed. In this report, we look at the current status of model animal construction and discuss which models require further development.

Keyword

Dengue virus; Vaccines; Animal models

MeSH Terms

Animals*
Climate Change
Dengue Virus
Dengue*
Endemic Diseases
Humans
Korea
Mice
Models, Animal*
Vaccines
Vaccines