Urogenit Tract Infect.  2017 Aug;12(2):77-81. 10.14777/uti.2017.12.2.77.

The Antibiotic Susceptibility of Escherichia coli from Community-Acquired Uncomplicated Urinary Tract Infection: A Focused on Fosfomycin

  • 1Department of Urology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
  • 2Department of Urology, Chung-Ang University School of Medicine, Seoul, Korea.
  • 3Department of Urology, Konkuk University School of Medicine, Chungju, Korea.
  • 4Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • 5Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea.
  • 6Department of Urology, Dongguk University School of Medicine, Gyeongju, Korea.
  • 7Department of Urology, National Police Hospital, Seoul, Korea.
  • 8Department of Urology, Chungnam National University School of Medicine, Daejeon, Korea.
  • 9Department of Urology, Ewha Womans University School of Medicine, Seoul, Korea.
  • 10Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
  • 11Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
  • 12Department of Urology, Kyung Hee University Medical Center, Seoul, Korea. sjlee@khu.ac.kr


To assess the antibiotic susceptibility of Escherichia coli from community-acquired uncomplicated urinary tract infection (UTI).
Between August and December of 2015, confirmed cases of E. coli as a pathogen of community-acquired uncomplicated UTI were collected and assessed for antibiotic susceptibility in 10 designated hospitals. Additional fosfomycin susceptibility test was performed by a central laboratory using the disk diffusion method.
A total of 347 E. coli isolates were collected from urine samples of community-acquired uncomplicated UTIs patients. The susceptibility rates of antibiotics were as follows: amikacin 100.0% (347), imipenem 100.0% (347), ciprofloxacin 57.1% (198), cefotaxime 74.9% (260), ampicillin 30.0% (104), trimethoprim/sulfamethoxazole 66.9% (232), and fosfomycin 98.0% (340). All fosfomycin-resistant E. coli isolates were extended-spectrum β-lactamase (ESBL)-producing. In 85 cases of ESBL-producing E. coli, the fosfomycin susceptibility rate was 91.8% (78/85).
Fosfomycin may be a useful option for the treatment of community-acquired uncomplicated UTIs. Further studies evaluating the role of fosfomycin in the treatment of UTIs and its clinical efficacy are necessary.


Drug resistance; Fosfomycin; Urinary tract infections
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