Clin Nutr Res.  2017 Jul;6(3):147-160. 10.7762/cnr.2017.6.3.147.

Chemopreventive and Chemotherapeutic Effects of Fish Oil derived Omega-3 Polyunsaturated Fatty Acids on Colon Carcinogenesis

Affiliations
  • 1Department of Food and Nutrition, College of Health and Wellness, Sungshin Women's University, Seoul 01133, Korea. nhkdec28@gmail.com
  • 2Department of Food Science and Biotechnology, College of Knowledge-Based Services Engineering, Sungshin Women's University, Seoul 01133, Korea.

Abstract

Colorectal cancer is the third most common cause of cancer related death in the world. Multiple lines of evidence suggest that there is an association between consumption of dietary fat and colon cancer risk. Not only the amount but also the type and the ratio of fatty acids comprising dietary fats consumed have been implicated in the etiology and pathogenesis of colon cancer. Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been known to inhibit development of colon cancer by downregulating the expression of genes involved in colon carcinogenesis and also by altering the membrane lipid composition. Data from laboratory, epidemiological, and clinical studies substantiate the beneficial role of n-3 PUFAs in preventing colitis and subsequent development of colon cancer. In addition, recent studies suggest that some n-3 PUFAs can be effective as an adjuvant with chemotherapeutic agents and other natural anticancer compounds in the management of colon cancer. In this review, we discuss chemopreventive and therapeutic effects of fish oil derived long chain n-3 PUFAs, particularly EPA and DHA, with focus on synergetic effects of which they exert when combined with chemotherapeutic agents and other natural compounds.

Keyword

Fatty acids, omega-3; EPA/DHA; Colorectal cancer; Cancer prevention; Therapeutic agent

MeSH Terms

Carcinogenesis*
Colitis
Colon*
Colonic Neoplasms
Colorectal Neoplasms
Dietary Fats
Eicosapentaenoic Acid
Fatty Acids
Fatty Acids, Omega-3
Fatty Acids, Unsaturated*
Fish Oils*
Membranes
Therapeutic Uses
Dietary Fats
Eicosapentaenoic Acid
Fatty Acids
Fatty Acids, Omega-3
Fatty Acids, Unsaturated
Fish Oils
Therapeutic Uses

Figure

  • Figure 1 Metabolic formation of EPA and DHA and their conversion to anti-inflammatory and pro-resolving metabolites with chemopreventive and therapeutic potentials. EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; n-3, omega-3; ASA, aspirin; COX-2, cyclooxygenase-2; CYP450, cytochrome P450; 18S-HEPE, 18S-hydroxyeicosapentaenoic acid; 18R-HEPE, 18R-hydroxyeicosapentaenoic acid; 18S-RvE1, 18S-resolvin E1; RvE1, resolvins E1; 5-LOX, 5-lipoxygenase; 17S-HDHA, 17S-hydroxy docosahexaenoic acid; 17R-HDHA, 17R-hydroxy docosahexaenoic acid; PD1, protectin D1; RvD1, resolvin D1; 17R-RvD1, 17R-resolvin D1.

  • Figure 2 Chemotherapeutic effects of n-3 PUFAs on colon carcinogenesis. n-3, omega-3; PUFAs, polyunsaturated fatty acids; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; n-6, omega-6.


Cited by  1 articles

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Sang Hoon Kim, Dong Hwan Park, Yun Jeong Lim
Korean J Gastroenterol. 2023;82(2):73-83.    doi: 10.4166/kjg.2023.079.


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