Int Neurourol J.  2015 Sep;19(3):197-206. 10.5213/inj.2015.19.3.197.

Alcohol, Smoking, Physical Activity, Protein, and Lower Urinary Tract Symptoms: Prospective Longitudinal Cohort

• Choo MS
• Han JH
• Shin TY
• Ko K
• Lee WK
• Cho ST
• Lee SK
• Lee SH

• KMID: 2380850
• DOI: http://doi.org/10.5213/inj.2015.19.3.197

Abstract

PURPOSE
To evaluate risk factors for deterioration of lower urinary tract symptoms (LUTS) in elderly men in a community-based, prospective longitudinal cohort study.
METHODS
In a suburban area in Korea, 1,514 subjects aged > or =45 years were randomly selected by systematic sampling. A total of 918 elderly subjects were enrolled in this in-depth clinical study in 2004. Of these, 547 participants were followed up for 3 years and the data was analyzed in 2014. Standard questionnaires were administered face-to-face by trained interviewers. After excluding women, 224 male participants with complete data including transrectal ultrasonography were included in the final analysis. LUTS were diagnosed using the International Prostate Symptom Score (IPSS) questionnaire. Symptom deterioration was defined as a score of > or =8 points during the 3-year follow-up period.
RESULTS
LUTS prevalence increased to 13.1% and the mean IPSS increased by 2.6 points during the 3-year period. After adjusting for confounders, a smoking history of > or =50 pack-years was an independent risk factor for deterioration of LUTS and storage subsymptoms compared with no history of smoking (3.1 and 5.1 odds, respectively). Physical activity had a protective effect on voiding subsymptoms. However, high protein diet and alcohol intake were not associated with LUTS deterioration.
CONCLUSIONS
The LUTS prevalence among elderly men living in a suburban area increased to 13.1% and the IPSS increased by 2.6 points during the 3-year period. A history of heavy smoking, low physical activity, and high protein intake were associated with LUTS deterioration. However, there was no significant association between alcohol intake and LUTS deterioration.

Keyword

Lower Urinary Tract Symptoms; Disease Progression; Smoking; Motor Activity; Dietary Proteins

MeSH Terms

Aged
Cohort Studies*
Diet
Dietary Proteins
Disease Progression
Female
Follow-Up Studies
Humans
Korea
Lower Urinary Tract Symptoms*
Male
Motor Activity*
Prevalence
Prospective Studies*
Prostate
Risk Factors
Smoke*
Smoking*
Ultrasonography
Dietary Proteins
Smoke