Clin Exp Otorhinolaryngol.  2017 Jun;10(2):143-147. 10.21053/ceo.2016.00346.

Serum Uric Acid Relation for Hearing Threshold Shift

Affiliations
  • 1Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan. weiliang0508@gmail.com
  • 2Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan.
  • 3Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
  • 4Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.

Abstract


OBJECTIVES
The effects of serum uric acid (UA) level on a variety of diseases were found from experimental and observational studies via oxidative stress and anti-oxidants. However, research on the association of UA and hearing thresholds is relatively sparse. We investigated this issue in the U.S. general population to evaluate the relationship of serum UA levels and pure tone threshold of hearing.
METHODS
Forty four thousand eighty four eligible participants aged 20 to 69 years who have serum UA data and received Audiometry Examination Component were enrolled from the National Health and Nutrition Examination Survey 1999-2004. Hearing thresholds (dB) as a pure tone average at low frequencies (0.5, 1, 2 kHz) and at high frequencies (3, 4, 6, and 8 kHz) were computed. Multivariate linear regression models and tertile-based analysis with an extended-model approach for covariates adjustment were used to assess the correlation between serum UA level and hearing thresholds.
RESULTS
In the adjusted mode of tertile-based analysis, the regression coefficients elucidated as the change of log-transformed mean hearing thresholds upon comparing participants in the highest tertile of serum UA to those in the lowest tertile were -0.067 (P=0.023) in high frequency and -0.058 (P=0.054) in low frequency. After adjusting for multiple pertinent covariates, inverse association between tertiles of serum UA and hearing thresholds remained essentially unchanged. The negative trends between serum UA and hearing thresholds were statistically significant (P for trends <0.05) in tertile-based multiple linear regressions.
CONCLUSION
Individuals with elevated UA levels independently were found to be inversely associated with hearing thresholds for pure tone audiometry in a nationally representative sample of U.S. adults.

Keyword

Uric Acid; Hearing; Antioxidants; Neuroprotection

MeSH Terms

Adult
Antioxidants
Audiometry
Hearing*
Humans
Linear Models
Neuroprotection
Nutrition Surveys
Oxidative Stress
Uric Acid*
Antioxidants
Uric Acid

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Clin Exp Otorhinolaryngol. 2017;10(3):221-227.    doi: 10.21053/ceo.2016.00787.


Reference

1. Hershfield MS, Roberts LJ 2nd, Ganson NJ, Kelly SJ, Santisteban I, Scarlett E, et al. Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo. Proc Natl Acad Sci U S A. 2010; Aug. 107(32):14351–6.
Article
2. Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, et al. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension. 2003; Jun. 41(6):1183–90.
Article
3. Verdecchia P, Schillaci G, Reboldi G, Santeusanio F, Porcellati C, Brunetti P. Relation between serum uric acid and risk of cardiovascular disease in essential hypertension: the PIUMA study. Hypertension. 2000; Dec. 36(6):1072–8.
4. Holme I, Aastveit AH, Hammar N, Jungner I, Walldius G. Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). J Intern Med. 2009; Dec. 266(6):558–70.
Article
5. Bergamini C, Cicoira M, Rossi A, Vassanelli C. Oxidative stress and hyperuricaemia: pathophysiology, clinical relevance, and therapeutic implications in chronic heart failure. Eur J Heart Fail. 2009; May. 11(5):444–52.
Article
6. Dehghan A, van Hoek M, Sijbrands EJ, Hofman A, Witteman JC. High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes Care. 2008; Feb. 31(2):361–2.
Article
7. Nakagawa T, Cirillo P, Sato W, Gersch M, Sautin Y, Roncal C, et al. The conundrum of hyperuricemia, metabolic syndrome, and renal disease. Intern Emerg Med. 2008; Dec. 3(4):313–8.
Article
8. Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A. 1981; Nov. 78(11):6858–62.
Article
9. Wu Y, Zhang D, Pang Z, Jiang W, Wang S, Tan Q. Association of serum uric acid level with muscle strength and cognitive function among Chinese aged 50-74 years. Geriatr Gerontol Int. 2013; Jul. 13(3):672–7.
Article
10. Rentzos M, Nikolaou C, Anagnostouli M, Rombos A, Tsakanikas K, Economou M, et al. Serum uric acid and multiple sclerosis. Clin Neurol Neurosurg. 2006; Sep. 108(6):527–31.
Article
11. Qin XL, Zhang QS, Sun L, Hao MW, Hu ZT. Lower serum bilirubin and uric acid concentrations in patients with Parkinson’s disease in China. Cell Biochem Biophys. 2015; May. 72(1):49–56.
Article
12. Kim TS, Pae CU, Yoon SJ, Jang WY, Lee NJ, Kim JJ, et al. Decreased plasma antioxidants in patients with Alzheimer’s disease. Int J Geriatr Psychiatry. 2006; Apr. 21(4):344–8.
Article
13. Centers for Disease Control and Prevention; National Center for Health Statistics. National Health and Nutrition Examination Survey: 1999-2000 data documentation, codebook, and frequencies. Audiometry (AUX1) [Internet]. Atlanta: Centers for Disease Control and Prevention;c2002. [cited 2016 Aug 10]. Available from: https://wwwn.cdc.gov/Nchs/Nhanes/1999-2000/ALQ.htm.
14. Centers for Disease Control and Prevention; National Center for Health Statistics. National Health And Nutrition Examination Survey: questionnaires, datasets, and related documentation [Internet]. Atlanta: Centers for Disease Control and Prevention;c2015. [cited 2015 Feb 21]. Available from: http://www.cdc.gov/nchs/nhanes/nhanes_questionnaires.htm.
15. Glantzounis GK, Tsimoyiannis EC, Kappas AM, Galaris DA. Uric acid and oxidative stress. Curr Pharm Des. 2005; 11(32):4145–51.
Article
16. Ciorba A, Gasparini P, Chicca M, Pinamonti S, Martini A. Reactive oxygen species in human inner ear perilymph. Acta Otolaryngol. 2010; Feb. 130(2):240–6.
Article
17. Henderson D, Bielefeld EC, Harris KC, Hu BH. The role of oxidative stress in noise-induced hearing loss. Ear Hear. 2006; Feb. 27(1):1–19.
Article
18. Clerici WJ, Yang L. Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function. Hear Res. 1996; Nov. 101(1-2):14–22.
Article
19. Lorito G, Giordano P, Prosser S, Martini A, Hatzopoulos S. Noise-induced hearing loss: a study on the pharmacological protection in the Sprague Dawley rat with N-acetyl-cysteine. Acta Otorhinolaryngol Ital. 2006; Jun. 26(3):133–9.
20. Kutzing MK, Firestein BL. Altered uric acid levels and disease states. J Pharmacol Exp Ther. 2008; Jan. 324(1):1–7.
Article
21. Sautin YY, Johnson RJ. Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids. 2008; Jun. 27(6):608–19.
Article
22. Kang DH, Ha SK. Uric acid puzzle: dual role as anti-oxidantand pro-oxidant. Electrolyte Blood Press. 2014; Jun. 12(1):1–6.
Article
23. Muraoka S, Miura T. Inhibition by uric acid of free radicals that damage biological molecules. Pharmacol Toxicol. 2003; Dec. 93(6):284–9.
Article
24. Lippi G, Montagnana M, Franchini M, Favaloro EJ, Targher G. The paradoxical relationship between serum uric acid and cardiovascular disease. Clin Chim Acta. 2008; Jun. 392(1-2):1–7.
Article
25. Waring WS, Convery A, Mishra V, Shenkin A, Webb DJ, Maxwell SR. Uric acid reduces exercise-induced oxidative stress in healthy adults. Clin Sci (Lond). 2003; Oct. 105(4):425–30.
Article
26. Waring WS, McKnight JA, Webb DJ, Maxwell SR. Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers. Diabetes. 2006; Nov. 55(11):3127–32.
Article
27. de Lau LM, Koudstaal PJ, Hofman A, Breteler MM. Serum uric acid levels and the risk of Parkinson disease. Ann Neurol. 2005; Nov. 58(5):797–800.
Article
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