Infect Chemother.
2017 Mar;49(1):57-61. 10.3947/ic.2017.49.1.57.
Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria
- Affiliations
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- 1Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea. symonlee@catholic.ac.kr
- 2Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- KMID: 2375100
- DOI: http://doi.org/10.3947/ic.2017.49.1.57
Abstract
- Animal models are essential to studies of infectious diseases. The use of mice to test bacterial infection has been extensively reported. However, methods applied to clinical isolates, particularly for carbapenem-resistant bacteria, must be tailored according to the infection models and bacteria used. In this study, we infected 6-week-old female BALB/c mice intraperitoneally with different strains of resistant bacteria plus 3% hog gastric mucin. This method was found to be efficient and readily applicable for investigation of carbapenem-resisant Gram-negative pathogens (e.g., Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii) detected in Korea.
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