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Antibiotics for multidrug-resistant gram-negative bacteria

Kang CI

Background: Increase in antimicrobial-resistant bacteria continues to be challenge to physicians. Particularly, multidrug-resistant (MDR) gram-negative bacilli (GNB), such as extended-spectrum beta-lactamase (ESBL)-producers and carbapenem-resistant pathogens, are becoming a major human...
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Multidrug-Resistant Gram-Negative Bacterial Infections in a Tertiary-Care Hospital in Northern Ghana: A Three-Year Retrospective Analysis

Osei KM, Choi H, Zeyeh DE, Alikamatu S, Boateng EO, Nov V, Nguyen LP, Kubura K, Bobzah B, Yong D

Background: A variety of clinically important pathogens have developed multidrug resistance (MDR), which threatens global public health. This study aimed to determine the incidence, patterns, and trends of MDR of...
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Brevundimonas Species Keratitis in a Patient without Underlying Disease

Jeong DE, Cha YW, Koh JW

Purpose: To report a case of keratitis caused by Brevundimonas diminuta/vesicularis. Case summary: A 20-year-old man presented with decreased visual acuity and glare in his right eye from 2 days earlier....
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A Case of Severe Hyperammonemic Encephalopathy Caused by Urinary Tract Infection in Obstructive Uropathy

Mun BG, Lee JH, Park YS, Jung J

Hyperammonemia is mainly caused by diseases related to liver failure. However, there are also non-hepatic causes of hyperammonemia, such as urinary tract infection (UTI) due to urease-producing organisms. Urease production...
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Antibiotic-Resistant Gram-negative Bacteria Carriage in Healthcare Workers Working in an Intensive Care Unit

Duong BT, Duong MC, Campbell J, Nguyen VMH, Nguyen HH, Hanh Bui TB, Nguyen VVC, McLaws ML

Little is known about antibiotic-resistant Gram-negative bacteria (GNB) intestinal carriage among healthcare workers (HCWs) in Vietnam. All HCWs at a tertiary intensive care units were asked to undertake weekly rectal...
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Clinical Characteristics and Causative Pathogens of Infective Arthritis and Risk Factors for Gram-Negative Bacterial Infections

Lee Y, Cho YS, Sohn YJ, Hyun JH, Ahn SM, Lee WJ, Kim JH, Seong H, Kim J, Jeong SJ, Ku NS, Yeom JS, Ahn JY, Choi JY

Background: The aim of this study was to describe the clinical and microbiological characteristics of infective arthritis and to analyze risk factors for Gram-negative bacterial infections that cause infective arthritis. Materials...
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Shorter Incubation Times for Detecting Multi-drug Resistant Bacteria in Patient Samples: Defining Early Imaging Time Points Using Growth Kinetics and Total Laboratory Automation

Burckhardt I, Last K, Zimmermann S

BACKGROUND: The transition from manual processing of patient samples to automated workflows in medical microbiology is challenging. Although automation enables microbiologists to evaluate all samples following the same incubation period,...
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Antimicrobial Therapy for Infections Caused by Carbapenem-Resistant Gram-Negative Bacteria

Wi YM, Kang CI

Carbapenem-resistance emerging in Gram-negative pathogens, such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, has become a major human health problem globally. The therapeutic options available for carbapenem-resistant pathogens are...
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Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea

Kim YA, Park YS

Antimicrobial resistance is becoming one of the greatest challenges to public health worldwide. Infections by antimicrobial-resistant organisms could result in the failure of treatment, increased medical costs, prolonged hospital stays,...
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Evaluation of Six Phenotypic Methods for the Detection of Carbapenemases in Gram-Negative Bacteria With Characterized Resistance Mechanisms

Sun K, Xu X, Yan J, Zhang L

BACKGROUND: We compared the performance of the modified Hodge test (MHT), Triton Hodge test (THT), Carba NP test (CNPt), simplified Carba NP test (CNPt-direct), blue-Carba NP test (BCT), and carbapenem...
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Changes in Renal Function by Nebulized Colistimethate Treatment

Ahn HJ, Jung YJ, Kim JS, Kim SH, Son ES

BACKGROUND: Nebulized colistimethate is increasingly used, because there are problems such as renal dysfunction and low distribution within the lungs when colistimethate is administered intravenously. This study was designed to...
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Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria

Park JY, Park C, Chun HS, Byun JH, Cho SY, Lee DG

Animal models are essential to studies of infectious diseases. The use of mice to test bacterial infection has been extensively reported. However, methods applied to clinical isolates, particularly for carbapenem-resistant...
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Epizootiological characteristics of viable bacteria and fungi in indoor air from porcine, chicken, or bovine husbandry confinement buildings

Roque K, Lim GD, Jo JH, Shin KM, Song ES, Gautam R, Kim CY, Lee K, Shin S, Yoo HS, Heo Y, Kim HA

Microorganisms found in bioaerosols from animal confinement buildings not only foster the risk of spreading diseases among livestock buildings, but also pose health hazards to farm workers and nearby residents....
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Gram-Negative Bacterial Keratitis: A 15-Year Review of Clinical Aspects

Cho EY, Lee SB

PURPOSE: In this study we investigated pathogenic organisms, antibiotic susceptibility, and clinical characteristics of patients with Gram-negative bacterial keratitis and elucidated risk factors for poor visual outcomes. METHODS: The authors performed...
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In vitro Antibacterial Activity of Doripenem against Gram-Negative Blood Isolates in a Korean Tertiary Care Center

Choi SH, Ahn MY, Chung JW, Lee MK

BACKGROUND: Doripenem is the most recently introduced antimicrobial agent of the carbapenem class. It is a valuable therapeutic option in the context of increasing antimicrobial resistance to imipenem and meropenem...
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Antimicrobial Therapy for Infections Caused by Multidrug-Resistant Gram-Negative Bacteria

Kang CI

The incidence of infections caused by multidrug-resistant (MDR) Gram-negative bacteria has increased over the past decade and extensively drug-resistant (XDR) infections are now on the rise, especially in non-fermenters such...
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The Antimicrobial Activity of (-)-Epigallocatehin-3-Gallate and Green Tea Extracts against Pseudomonas aeruginosa and Escherichia coli Isolated from Skin Wounds

Jeon J, Kim JH, Lee CK, Oh CH, Song HJ

BACKGROUND: Skin infections with Gram-negative bacteria are sometimes challenging to treat, because these bacteria show multidrug resistance against commonly used antibiotics and patients with Gram-negative bacterial infection overall have deteriorated...
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Delta Neutrophil Index as a Prognostic Marker of Early Mortality in Gram Negative Bacteremia

Kim HW, Yoon JH, Jin SJ, Kim SB, Ku NS, Jeong SJ, Han SH, Choi JY, Kim JM, Song YG

BACKGROUND: Sepsis is a syndrome that results in high morbidity and mortality. We investigated the delta neutrophil index (DN) as a predictive marker of early mortality in patients with gram-negative...
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In Vitro Antibacterial Efficacy of 21 Indian Timber-Yielding Plants Against Multidrug-Resistant Bacteria Causing Urinary Tract Infection

Mishra MP, Padhy RN

Objectives To screen methanolic leaf extracts of 21 timber-yielding plants for antibacterial activity against nine species of uropathogenic bacteria isolated from clinical samples of a hospital (Enterococcus faecalis, Staphylococcus aureus, Acinetobacter...
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Comparison of the Incidence and Clinical Characteristics of Gram-positive and Gram-negative Surgical Site Infections after Gastric Surgery

Kim HW, Kim CO, Jeong SJ, Han SH, Choi JY, Kim MJ, Choi YH, Im SG, Yeom JS, Park YS, Song YG, Choi HJ, Peck KR, Kang CI, Kim HY, Kim YK, Lee SS, Park DW, Kim YA, Choi SH, Kim JM

BACKGROUND: Surgical site infection (SSI) is prominent among the total incidence of healthcare-associated infections, and is a major contributing factor in the trend of increasing medical costs. There have been...
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