Endocrinol Metab.
2016 Dec;31(4):598-603. 10.3803/EnM.2016.31.4.598.
Obesity and Hyperglycemia in Korean Men with Klinefelter Syndrome: The Korean Endocrine Society Registry
- Affiliations
-
- 1Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea. yschung@ajou.ac.kr
- 2Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
- 3Department of Internal Medicine, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
- 4Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- 5Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 6Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
- 7Division of Endocrinology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
- 8Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
- 9Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
- 10Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
- 11Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 12Division of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
- 13Department of Endocrinology, Inha University School of Medicine, Incheon, Korea.
- KMID: 2373081
- DOI: http://doi.org/10.3803/EnM.2016.31.4.598
Abstract
- BACKGROUND
The aim of this study was to investigate the prevalence of obesity in Korean men with Klinefelter syndrome (KS) and the associated risk factors for obesity and hyperglycemia.
METHODS
Data were collected retrospectively from medical records from 11 university hospitals in Korea between 1994 and 2014. Subjects aged ≥18 years with newly diagnosed KS were enrolled. The following parameters were recorded at baseline before treatment: chief complaint, height, weight, fasting glucose level, lipid panel, blood pressure, testosterone, luteinizing hormone, follicle-stimulating hormone, karyotyping patterns, and history of hypertension, diabetes, and dyslipidemia.
RESULTS
Data were analyzed from 376 of 544 initially enrolled patients. The rate of the 47 XXY chromosomal pattern was 94.1%. The prevalence of obesity (body mass index ≥25 kg/m²) in Korean men with KS was 42.6%. The testosterone level was an independent risk factor for obesity and hyperglycemia.
CONCLUSION
Obesity is common in Korean men with KS. Hypogonadism in patients with KS was associated with obesity and hyperglycemia.
Keyword
MeSH Terms
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Blood Pressure
Dyslipidemias
Fasting
Follicle Stimulating Hormone
Glucose
Hospitals, University
Humans
Hyperglycemia*
Hypertension
Hypogonadism
Karyotyping
Klinefelter Syndrome*
Korea
Luteinizing Hormone
Male
Medical Records
Obesity*
Prevalence
Retrospective Studies
Risk Factors
Testosterone
Follicle Stimulating Hormone
Glucose
Luteinizing Hormone
Testosterone
Figure
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Fig. 1 Correlation among serum testosterone, body mass index (BMI), and fasting plasma glucose (FPG). (A) The association between testosterone and BMI. (B) The association between testosterone and FPG.
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