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Relationship between Hypogonadal Symptoms, Sexual Dysfunction and Chronic Prostatitis in Middle-Aged Men by Self-Reported Questionnaires, even without Biochemical Testosterone Deficiency

Lee MH, Seo DH, Lee CW, Choi JH, Jeh SU, Lee SW, Choi SM, Hwa JS, Hyun JS, Chung KH, Kam SC

PURPOSE: To investigate the association of erectile dysfunction (ED), premature ejaculation (PE), and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men with late-onset hypogonadism (LOH). MATERIALS AND METHODS: We reviewed the...
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Management of Anabolic Steroid-Induced Infertility: Novel Strategies for Fertility Maintenance and Recovery

Tatem AJ, Beilan J, Kovac JR, Lipshultz

There is often inherent conflict in the overlapping fields of male fertility and andrology. While the goal of all male fertility specialists is to facilitate and preserve biologic paternity, many...
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Testosterone Replacement Therapy for Patients with Hypogonadism after High Dose-Rate Brachytherapy for High-Risk Prostate Cancer: A Report of Six Cases and Literature Review

Kadomoto S, Shigehara , Iwamoto H, Yaegashi H, Izumi K, Kadono Y, Mizokami A

We had six cases of patients who were treated with long-term testosterone replacement therapy (TRT) after high dose-rate (HDR) brachytherapy and androgen deprivation therapy for high-risk prostate cancer. All patients...
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Cross-Sectional Association of Metabolic Syndrome and Its Components with Serum Testosterone Levels in a Korean-Screened Population

Kim M, Kyung YS, Ahn TY

PURPOSE: We evaluated the associations of metabolic syndrome (MetS) and its components with testosterone levels in the Korean population. MATERIALS AND METHODS: This cross-sectional study was performed among 6,967 adult (age≥20...
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Long-Term Testosterone Therapy in Type 2 Diabetes Is Associated with Decreasing Waist Circumference and Improving Erectile Function

Hackett G, Cole N, Mulay A, Strange RC, Ramachandran S

PURPOSE: To describe the 4-year metabolic follow-up results from the BLAST study. MATERIALS AND METHODS: Baseline hemoglobin A1c (HbA1c), weight, and waist circumference (WC) data were recorded in 185 men recruited...
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Pituitary magnetic resonance imaging abnormalities in young female patients with hypogonadotropic hypogonadism

Kang JY, Kim SH, Kim H, Ki H, Lee MH

OBJECTIVE: To elucidate the association between clinical and laboratory characteristics and pituitary magnetic resonance imaging (MRI) abnormalities in young female patients with hypogonadotropic hypogonadism (HH). METHODS: We retrospectively investigated a series...
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Metabolic Syndrome Is an Independent Risk Factor for Acquired Premature Ejaculation

Jeh SU, Yoon S, Choi JH, Do J, Seo DH, Lee SW, Choi SM, Lee C, Kam SC, Hwa JS, Chung KH, Kang HW, Hyun JS

PURPOSE: To determine the role of metabolic syndrome (MetS) as a risk factor for acquired premature ejaculation (PE) after considering the various risk factors, such as lower urinary tract symptoms,...
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Misuse of testosterone replacement therapy in men in infertile couples and its influence on infertility treatment

Song SH, Sung S, Her YS, Oh M, Shin DH, Lee J, Baek J, Lee WS, Kim DS

OBJECTIVE: We investigated the clinical characteristics of men with testosterone replacement therapy (TRT)-induced hypogonadism and its effect on assisted reproductive technology (ART) in infertile couples. METHODS: This study examined the records...
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Embryonal Carcinoma of the Pineal Gland Developed in an Adolescent Boy with Klinefelter Syndrome

Choi HJ, Kim EA, Lee JM, Jang KM, Choi JH

Klinefelter syndrome (KS) is characterized by small testes, gynecomastia, tall stature, and hypergonadotropic hypogonadism. This condition is associated with extra X chromosomes. It is well known that these aneuploidies predispose...
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Effect of Korean Herbal Formula (Modified Ojayeonjonghwan) on Androgen Receptor Expression in an Aging Rat Model of Late Onset Hypogonadism

Choi SW, Jeon SH, Kwon EB, Zhu GQ, Lee KW, Choi JB, Jeong HC, Kim KS, Bae SR, Bae WJ, Kim SJ, Cho HJ, Ha US, Hong SH, Hwang SY, Kim SW

PURPOSE: Testosterone replacement therapy is an effective treatment for late-onset hypogonadism (LOH) despite a few contraindications and side-effects. The aim of this study was to determine whether modified Ojayeonjonghwan (KH-204,...
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Elevated Body Mass Index Is Associated with Secondary Hypogonadism among Men Presenting to a Tertiary Academic Medical Center

Masterson , Soodana-Prakash N, Patel AS, Kargi AY, Ramasamy R

PURPOSE: To characterize the population of hypogonadal men who presented to a tertiary academic urology clinic and evaluate risk factors for primary vs. secondary hypogonadism. MATERIALS AND METHODS: We evaluated all...
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Testosterone Is a Contraceptive and Should Not Be Used in Men Who Desire Fertility

Patel AS, Leong JY, Ramos L, Ramasamy R

Testosterone has a variety of functions and is commonly used in older men to treat symptoms of hypogonadism, such as decreased libido, decreased mood and erectile dysfunction. Despite its positive...
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Type 2 Diabetes and Testosterone Therapy

Hackett G

A third of men with type 2 diabetes (T2DM) have hypogonadotrophic hypogonadism (HH) and associated increased risk of cardiovascular and all-cause mortality. Men with HH are at increased risk of...
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Obstructive Sleep Apnea and Testosterone Deficiency

Kim SD, Cho KS

Obstructive sleep apnea (OSA) is a common disorder characterized by intermittent hypoxia and sleep fragmentation. OSA in middle-aged men is often associated with decreased testosterone secretion, together with obesity and...
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Testicular microlithiasis in a boy with X-linked adrenal hypoplasia congenita

Serbis A, Tsinopoulou VR, Mouzaki K, Kotanidou , Giza S, Galli-Tsinopoulou A

X-linked adrenal hypoplasia congenita (AHC) is a rare disorder that usually presents clinically as adrenal insufficiency in early infancy. It is caused by mutations in the NR0B1 gene which is...
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Efficacy and Safety of a Mixed Extract of Trigonella foenum-graecum Seed and Lespedeza cuneata in the Treatment of Testosterone Deficiency Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Park HJ, Lee KS, Lee EK, Park NC

PURPOSE: The aim of this study was to investigate the efficacy and safety of a mixed extract of Trigonella foenum-graecum seed and Lespedeza cuneata (TFGL) for the treatment of testosterone...
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Impact of Testosterone Deficiency and Testosterone Therapy on Lower Urinary Tract Symptoms in Men with Metabolic Syndrome

Traish AM, Johansen V

Lower urinary tract function is modulated by neural, vascular and urethral and bladder structural elements. The pathophysiological mechanisms of lower urinary tract symptoms (LUTS) encompass prostate enlargement, alterations in urethra...
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Delayed puberty versus hypogonadism: a challenge for the pediatrician

Bozzola M, Bozzola E, Montalbano C, Stamati FA, Ferrara P, Villani A

Constitutional delay of growth and puberty (CDGP) is the most common cause of delayed puberty (DP), is mainly found in males, and is characterized by short stature and delayed skeletal...
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Shifting the Paradigm of Testosterone Replacement Therapy in Prostate Cancer

Bell MA, Campbell J, Joice G, Sopko NA, Burnett AL

Historically, testosterone and prostate cancer have been demonstrated to have a positive association leading providers to forgo testosterone replacement therapy (TRT) in men with concurrent histories of hypogonadism and prostate...
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Emerging Evidences in the Long Standing Controversy Regarding Testosterone Replacement Therapy and Cardiovascular Events

Clavell-Hernández J, Wang R

The increasing rate of late-onset hypogonadism has led to an exceptional growth in the use of testosterone therapy (TTh). Even though TTh has been used for more than 70 years,...
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