J Korean Gastric Cancer Assoc.  2007 Dec;7(4):254-260.

Comparative Study of the Clinicopathologic Characteristics between Gastrointestinal Stromal Tumors Arising from the Stomach and Small Bowel

• Heo GW
• Shin DW
• Paik SY
• Kim ID
• Kim KH
• Suh BS
• Park JS
• Kim SW

Abstract

PURPOSE: The purpose of this study is to compare the clinicopathological characteristics of stomach and small bowel gastrointestinal stromal tumors and to determine the risk factors and treatment guidelines.
MATERIALS AND METHODS
Among 38 patients who were diagnosed with a gastrointestinal stromal tumor from August 1998 to May 2006, 29 patients at the Pundang Jesaeng General Hospital, Daejin Medical Center were evaluated. The clinicopathological characteristics of gastrointestinal stromal tumors arising from stomach and small bowel were compared. Immunohistochemical staining for CD117, CD34, smooth muscle actin, desmin, and S-100 protein was performed and classified according to NIH criteria. Prognosis between groups was analyzed according to NIH criteria.
RESULTS
There was no significant difference in the clinicopathological characteristics and prognosis between gastrointestinal stromal tumors arising from the stomach and small bowel. Recurrence of the disease occurred in four (13.8%) patients. Classification of gastrointestinal stromal tumors according to NIH criteria was predictive of recurrence (P=0.030).
CONCLUSION
NIH criteria were predictive of recurrence, but the location of the primary site was not predictive of recurrence. A further study involving multi center data and a long-term follow-up will be needed for formulating diagnostic and therapeutic guidelines.

Keyword

Gastrointestinal stromal tumors; Clinical characteristic; Risk factor; Treatment

MeSH Terms

Actins
Classification
Desmin
Follow-Up Studies
Gastrointestinal Stromal Tumors*
Hospitals, General
Humans
Muscle, Smooth
Prognosis
Recurrence
Risk Factors
S100 Proteins
Stomach*
Actins
Desmin
S100 Proteins