Ann Clin Neurophysiol.  2017 Jan;19(1):54-57. 10.14253/acn.2017.19.1.54.

Distal acquired demyelinating symmetric neuropathy associated with anti-GM1 and anti-GD1b antibodies

• Ko KH
• Jwa SJ
• Park SJ
• Kang SY

• KMID: 2367996
• DOI: http://doi.org/10.14253/acn.2017.19.1.54

Abstract

Distal acquired demyelinating symmetric (DADS) neuropathy is a variant form of chronic inflammatory demyelinating polyradiculoneuropathy. A 54-year-old man presented with gait disturbance owing to weakness in both legs. Nerve conduction studies showed demyelinating sensorimotor polyneuropathy, and laboratory studies demonstrated anti-GM1 and anti-GD1b IgG antibodies, but no anti-myelin associated glycoprotein activity. We suggest that an antiganglioside antibodies assay needs to be applied when DADS neuropathy is suspected in order to improve the classification of dysimmune neuropathies.

Keyword

Gangliosides; Antibodies; Demyelination; Neuropathy

MeSH Terms

Antibodies*
Classification
Demyelinating Diseases
Gait
Gangliosides
Glycoproteins
Humans
Immunoglobulin G
Leg
Middle Aged
Neural Conduction
Polyneuropathies
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Antibodies
Gangliosides
Glycoproteins
Immunoglobulin G

Reference

1.Barohn RJ., Kissel JT., Warmolts JR., Mendell JR. Chronic inflammatory demyelinating polyradiculoneuropathy. Clinical character-istics, course, and recommendations for diagnostic criteria. Arch Neurol. 1989. 46:878–884.

2.Katz JS., Saperstein DS., Gronseth G., Amato AA., Barohn RJ. Distal acquired demyelinating symmetric neuropathy. Neurology. 2000. 54:615–620.

3.Dimachkie MM., Barohn RJ., Katz J. Multifocal motor neuropathy, multifocal acquired demyelinating sensory and motor neuropathy, and other chronic acquired demyelinating polyneuropathy variants. Neurol Clin. 2013. 31:533–555.

4.O’Leary CP., Willison HJ. The role of antiglycolipid antibodies in peripheral neuropathies. Curr Opin Neurol. 2000. 13:583–588.

5.Larue S., Bombelli F., Viala K., Neil J., Maisonobe T., Bouche P, et al. Non-anti-MAG DADS neuropathy as a variant of CIDP: clinical, electrophysiological, laboratory features and response to treatment in 10 cases. Eur J Neurol. 2011. 18:899–905.

6.Remiche G., Kentos A., Mavroudakis N. Distal acquired demyelinating symmetric neuropathy associated with anti-GM1 antibod-ies: is this a CIDP variant? Acta Neurol Belg. 2010. 110:103–106.

7.Saperstein DS., Katz JS., Amato AA., Barohn RJ. Clinical spectrum of chronic acquired demyelinating polyneuropathies. Muscle Nerve. 2001. 24:311–324.

8.Nobile-Orazio E., Manfredini E., Carpo M., Meucci N., Monaco S., Ferrari S, et al. Frequency and clinical correlates of anti-neuronal IgM antibodies in neuropathy associated with IgM monoclonal gammopathy. Ann Neurol. 1994. 36:416–424.

9.Quarles RH., Weiss MD. Autoantibodies associated with peripheral neuropathy. Muscle Nerve. 1999. 22:800–822.

10.Rinaldi S., Willison HJ. Ganglioside antibodies and neuropathies. Curr Opin Neurol. 2008. 21:540–546.