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An Alternative Dendritic Cell-Induced Murine Model of Asthma Exhibiting a Robust Th2/Th17-Skewed Response

Park SC, Kim H, Bak Y, Shim D, Kwon KW, Kim CH, Yoon JH, Shin SJ

PURPOSE: Simple and reliable animal models of human diseases contribute to the understanding of disease pathogenesis as well as the development of therapeutic interventions. Although several murine models to mimic...
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Clinical Significance of Elevated Serum Immunoglobulin G4 Levels in Patients With Rheumatoid Arthritis

Kim SH, Jeong HJ, Kim JM, Jun JB, Son CN

OBJECTIVE: This study aimed to evaluate the relationship between serum immunoglobulin G4 (IgG4) levels and the presence and disease activity of rheumatoid arthritis (RA). METHODS: The study enrolled 128 participants (RA,...
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Expression and Purification of Recombinant Mayaro Virus Envelope Glycoproteins E1 and E2 to Develop a Mayaro Virus Detection System

Yi SY, Yoon K, Kwon J, Kim KE, Park K, Shin YB

Mayaro virus (MAYV) is a mosquito-transmitted alphavirus that produces an acute, usually non-fatal, febrile illness including Mayaro fever. Like other alphaviruses, the MAYV E1 and E2 envelope glycoproteins are major...
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In reply: the evaluation of IgG titers' stability from blood samples is necessary

Ouh YT, Lee JK

No abstract available.
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Evidence for the Presence of Long-Lived Plasma Cells in Nasal Polyps

Zhang YN, Song J, Zhai GT, Wang H, Luo RZ, Li JX, Liao B, Ma J, Wang H, Lu X, Liu DB, Liu Z

PURPOSE: Plasma cells and immunoglobulins (Igs) play a pivotal role in the induction and maintenance of chronic inflammation in nasal polyps. During secondary immune responses, plasma cell survival and Ig...
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Necrobiotic Xanthogranuloma Coexists with Diffuse Normolipidemic Plane Xanthoma and Multiple Myeloma

Kim JG, Kim HR, You MH, Shin DH, Choi JS, Bae YK

Necrobiotic xanthogranuloma (NXG), is a rare multisystem disease that manifests as cutaneous inflammatory lesions, and is commonly associated with lymphoproliferative disease. Diffuse normolipemic plane xanthoma (NX), is also a rare,...
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A case of IgG4-related disease associated with psoriasis-like skin rash and hypereosinophilic syndrome

Park HK, Han MH, Lee SJ

Immunoglobulin (Ig) G4-related disease (IgG4-RD) is newly recognized immune-mediated and fibroinflammatory conditions with various organ involvements. Any organs can be involved, but the pancreas, salivary gland, lymph nodes, and orbit...
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Recurrent Optic Neuritis and Acute Encephalopathy with Myelin Oligodendrocyte Glycoprotein Antibodies in a Korean Child

Hwang JE, Kim SH, Park S

Myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases are reported to have distinct pathogenic mechanisms, clinical courses, and therapeutic implications in comparison to other acquired demyelinating syndromes. Here, we report the case...
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Report of the Korean Association of External Quality Assessment Service on Complement and Immunoglobulin (2018)

Kim KH

In 2018, the complement and immunoglobulin proficiency testing program of the Korean Association of External Quality Assessment Service included complement, free light chain, immunoglobulin, and anti-cyclic citrullinated peptide (anti-CCP). Tests...
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Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT

Arora S, Damle NA, Meel R, Sharma S, Sen S, Bal C, Lata K, Prakash S, Yadav D, Angamuthu

Immunoglobulin G4 (IgG4)–related diseases are a spectrum of systemic inflammatory conditions of unknown etiology, which are characterized by infiltration of tissues by IgG4 plasma cells and sclerosing inflammation (Cheuk and...
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Autoantibody-Mediated Dysfunction of Salivary Glands Leads to Xerostomia in SKG Mice

Choi SS, Jang E, Jang K, Jung SJ, Hwang KG, Youn J

Sjögren's syndrome (SS) is a chronic heterogeneous disease that mainly affects exocrine glands, leading to sicca syndromes such as xerostomia. Despite the second highest prevalence rate among systemic autoimmune diseases,...
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Impact of Cytomegalovirus Disease on New-Onset Type 2 Diabetes Mellitus: Population-Based Matched Case-Control Cohort Study

Yoo SG, Han KD, Lee KH, La Y, Kwon DE, Han SH

BACKGROUND: A latent cytomegalovirus (CMV) cause chronic inflammation through undesirable inflation of cell-mediated immune response. CMV immunoglobulin G has been associated with cardiovascular disease and type 1 diabetes mellitus. We...
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The Eschar Size and Early Inoculation Lesion of Tsutsugamushi Disease on Jeju Island, Korea

Kim YH, Hyun W, Kim DP, Chung MH, Im JH, Baek JH, Lee JS, Kang JS

BACKGROUND: Tsutsugamushi disease, or scrub typhus, is an acute febrile illness caused by Orientia tsutsugamushi, which is followed by chronic latent infection. People who reside in areas endemic of tsutsugamushi...
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Seroprevalence of Severe Fever with Thrombocytopenia Syndrome in the Agricultural Population of Jeju Island, Korea, 2015–2017

Yoo JR, Heo ST, Kim M, Song SW, Boo JW, Lee KH

BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne zoonotic disease that is caused by the SFTS virus (SFTSV), and exhibits an overall mortality rate of approximately 20.0% in...
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Lichen Planus Developed During the Treatment with Nivolumab in a Patient with Lung Cancer: A Case Report and Literature Review

Park E, Koo T, Jo M, Yoo J, Park J

  • KMID: 2465922
  • Korean J Dermatol.
  • 2019 Nov;57(9):551-555.
Nivolumab is a fully-humanized IgG4 monoclonal antibody that competitively binds to the programmed cell death receptor-1 protein (an immune check-point molecule) present on activated T cells. Nivolumab is approved for...
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Concurrent Anti-glomerular Basement Membrane Nephritis and IgA Nephropathy

Suh KS, Choi SY, Bae GE, Choi DE, Yeo MK

Anti–glomerular basement membrane (GBM) nephritis is characterized by circulating anti-GBM antibodies and crescentic glomerulonephritis (GN) with deposition of IgG along the GBM. In a limited number of cases, glomerular immune...
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Seropositive rate of the anti-hepatitis A immunoglobulin G antibody in maintenance hemodialysis subjects from two hospitals in Korea

Kim H, Ryu J, Lee YK, Choi MJ, Cho A, Koo JR, Baik SY, Lee EH, Yoon JW, Noh JW

BACKGROUND/AIMS: Hepatitis A virus (HAV) is a self-limiting infectious disease, but 1% of subjects develop fulminant hepatitis. The prevalence of the anti-HAV immunoglobulin G (IgG) antibody in hemodialysis subjects in...
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EDTA Treatment for Overcoming the Prozone Effect and for Predicting C1q Binding in HLA Antibody Testing

Kim HS, Choi AR, Yang M, Oh EJ

The Luminex-based single antigen bead (SAB) assay is widely used to detect HLA antibody in transplant recipients. However, one limitation of the SAB assay is the prozone effect, which occurs...
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Comparison of Six Commercial Diagnostic Tests for the Detection of Dengue Virus Non-Structural-1 Antigen and IgM/IgG Antibodies

Lee H, Ryu JH, Park HS, Park KH, Bae H, Yun S, Choi AR, Cho SY, Park C, Lee DG, Lim J, Lee J, Lee S, Shin S, Park H, Oh EJ

ELISAs and rapid diagnostic tests (RDTs) are widely used for diagnosing dengue virus (DENV) infection. Using 138 single blood samples, we compared the ability to detect non-structural (NS)-1 antigen and...
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Virus-like Particle Vaccine Containing Toxoplasma gondii Rhoptry Protein 13 Induces Protection against T. gondii ME49 Infection in Mice

Kang HJ, Chu KB, Lee SH, Kim MJ, Park H, Jin H, Quan FS

Toxoplasma gondii can infect humans worldwide, causing serious diseases in pregnant women and immunocompromised individuals. T. gondii rhoptry protein 13 (ROP13) is known as one of the key proteins involved...
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