J Korean Neuropsychiatr Assoc.  2006 Sep;45(5):481-483.

Seizure and Thyroid Dysfunction Associated with High Dose of Quetiapine: Case Report

• Choi SH
• Kang SH
• Kim CY

Abstract

We report a case of seizure and thyroid dysfunction in a patient receiving quetiapine. A 31-year-old Korean woman with bipolar I disorder was observed to have a seizure attack after reduction of quetiapine from 1,200 mg/day to 1,000 mg/day and discontinuance of clonazepam 1 mg/day. Her thyroid function test also showed hyperthyroidism after quetiapine use. She had no known risk factors of seizure, and no known history of lithium ingestion. The patient was taking high dose quetiapine due to her manic symptoms. Using high dose of quetiapine may have resulted in a seizure attack in our patient with bipolar I disorder. Also, in this patient, quetiapine was probably associated with hyperthyroidism. It is not common that seizure occur with atypical antipsychotics, such as quetiapine, except clozapine, but special attention is required using high dose of atypical antipsychotics.

Keyword

Bipolar I disorder; Atypical antipsychotics; Quetiapine; Seizure; Hyperthyrodism

MeSH Terms

Adult
Antipsychotic Agents
Clonazepam
Clozapine
Eating
Female
Humans
Hyperthyroidism
Lithium
Risk Factors
Seizures*
Thyroid Function Tests
Thyroid Gland*
Quetiapine Fumarate
Antipsychotic Agents
Clonazepam
Clozapine
Lithium