Endocrinol Metab.  2010 Sep;25(3):231-235. 10.3803/EnM.2010.25.3.231.

New Onset Diabetic Ketoacidosis Associated with Quetiapine

Affiliations
  • 1Kim Yong Ki Internal Medical Center, Busan, Korea. sohylee@hanmail.net

Abstract

New onset diabetes and diabetic ketoacidosis have been reported with administering atypical antipsychotics. Whereas clozapine and olanzapine are associated with a relatively high incidence of new onset diabetes and diabetic ketoacidosis, there are few case reports that have has been documented implicating quetiapine as the contributor to causing diabetes and diabetic ketoacidosis. I report here on a case of diabetic ketoacidosis that developed in a patient who was associated with quetiapine therapy. A 32-year-old woman with schizophrenia was transferred to the emergency room with diabetic ketoacidosis and vaginal bleeding. Seventeen months before this episode, she was hospitalized in an inpatient psychiatric institution and treated with quetiapine 1200mg, haloperidol 3mg, diazepam 5mg and benztropine 3mg with normal blood glucose levels. She had no personal and familial history of diabetes mellitus. She had no risk factors for diabetes mellitus and she also had no precipitating factor for diabetic ketoacidosis except for taking the atypical antipsychotic quetiapine. I believe that this case is the first case report of quetiapine associated diabetic ketoacidosis in Korea. Considering the unpredictability of hyperglycemia associated with quetiapine, monitoring the blood glucose should be part of the routine care when administering quetiapine.

Keyword

Diabetic Ketoacidosis; Quetiapine

MeSH Terms

Adult
Antipsychotic Agents
Benzodiazepines
Benztropine
Blood Glucose
Clozapine
Diabetes Mellitus
Diabetic Ketoacidosis
Diazepam
Dibenzothiazepines
Emergencies
Female
Haloperidol
Humans
Hyperglycemia
Incidence
Inpatients
Korea
Precipitating Factors
Risk Factors
Schizophrenia
Uterine Hemorrhage
Quetiapine Fumarate
Antipsychotic Agents
Benzodiazepines
Benztropine
Blood Glucose
Clozapine
Diazepam
Dibenzothiazepines
Haloperidol
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