J Korean Neuropsychiatr Assoc.  2004 May;43(3):277-282.

Polymorphisms of TAP2 Gene in Schizophrenia

Affiliations
  • 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract


OBJECTIVES
The genes for transporters associated with antigen processing (TAP) are located near to HLA class II coding regions and related to antigen presentation. Therefore polymorphisms of TAP might alter the T-cell mediated immune response and influence susceptibility to schizophrenia, which is known to have alterations in T-cell immunity. The aim of this study was to verify the relationship between schizophrenia and polymorphisms of TAP2 genes.
METHODS
257 patients with schizophrenia and 184 normal controls participated in this study. TAP2 polymorphic residues at positions 379, 565 and 665 were typed using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and single-strand conformation polymorphism (SSCP). The resulted products, TAP2379, TAP2565 and TAP2665 were assessed.
RESULTS
The frequency of TAP2 alleles did not differ between patients with schizophrenia and controls. The polymorphic sites TAP2379, TAP2565 and TAP2665 did not show any difference in their amino acid substitution frequencies.
CONCLUSION
This study did not show the association of the TAP2 gene with schizophrenia in Korean population. Further studies are needed to test the informative value of haplotypes including other polymorphic sites.

Keyword

Schizophrenia; TAP2 haplotype; Polymorphisms

MeSH Terms

Alleles
Amino Acid Substitution
Antigen Presentation
Clinical Coding
Haplotypes
Humans
Schizophrenia*
T-Lymphocytes
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