J Korean Neuropsychiatr Assoc.
2002 Sep;41(5):942-946.
Atypical Antipsychotic Drug Induced Diabetes Mellitus
- Affiliations
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- 1Department of Neuropsychiatry, College of Medicine, Kangwon National University, Chuncheon, Korea.
- 2Neuroscience Research Institute, Seoul National University Medical Research Center, Seoul, Korea.
- 3Department of Neuropsychiatry, Eulji University School of Medicine, Seoul, Korea.
- 4Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
Abstract
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BACKGROUND: Atypical antipsychotics have been reported to affect glucose-insulin homeostasis and possibly induce diabetes mellitus. Here, we present five cases in which clozapine or olanzapine treatment were associated with de novo onset of diabetes mellitus.
CASE REPORT
S: Three out of the five cases had risk factors for diabetes and developed diabetes during the early phase of treatment with atypical antipsychotics. However, it took longer for the other two patients with no risk factor for diabetes to manifest symptoms of diabetes. In all of the cases, we were able to control their plasma glucose level within clinically tolerable range by applying diverse treatment modalities for diabetes mellitus and continue with antipsychotics treatment.
CONCLUSION
These findings suggest that risk factors for diabetes such as family history of diabetes and baseline obesity may be related to development and time of onset of atypical antipsychotic drugs induced diabetes.
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