J Korean Neuropsychiatr Assoc.  2001 May;40(3):503-509.

Apolipoprotein E Polymorphism in Schizophrenic Patients

• Choi YS
• Lim CK
• Lyoo CH

Abstract

OBJECTIVES
To explore the role of apolipoprotein E in schizophrenia, we investigated apoli-poprotein E polymorphism in groups of patients with schizophrenia and normal controls. We also examined the relationship of clinical characteristics of schizophrenia to apolipoprotein E genotypes.
METHODS
Samples were obtained from 101 schizophrenic patients and 96 controls in Korea and apolipoprotein E polymorphisms were analysed using polymerase chain reaction.
RESULTS
The genotype and allele frequencies did not differ from those of controls. The clinical variables of schizophrenia, such as positive and negative groups by PANSS, subtypes by DSM-IV, family history were not associated with each genotypes.
CONCLUSION
We could not find the association of apolipoprotein E in Korean schizophrenic patients and it could be suggested that apolipoprotein E isoforms might not play a main role in expression of schizophrenia.

Keyword

Schizophrenia; Apolipoprotein E; Genotype

MeSH Terms

Apolipoproteins*
Diagnostic and Statistical Manual of Mental Disorders
Gene Frequency
Genotype
Humans
Korea
Polymerase Chain Reaction
Protein Isoforms
Schizophrenia
Apolipoproteins
Protein Isoforms