J Korean Pain Soc.  2000 Jun;13(1):55-59.

Postoperative Analgesia of Intrathecal Morphine and Intramuscular Caroverine and Tiaprofenate in Transurethral Resection of the Prostate

• Kim JS
• Sun KT
• Kim YS
• Leuloe KC
• Kang PS
• Lee YC

Abstract

BACKGROUND: Intrathecal injection of morphine is widely used in the management of postoperative pain because it provides long-lasting analgesia. Intramuscular caroverine and tiaprofenate are used to produce postoperative pain relief. This study was designed to evaluate the analgesic efficacy and quality of sleep achieved with intrathecal morphine and those of intramuseular caroverine and tiaprofenate in transurethral resection of the prostate (TURP).
METHODS
Forty patients undergoing elective TURP were randomly allocated into 2 groups as follows: Group M (n 20); 0.25 mg of morphine hydrochloride mixed in 7.5 mg of 0.5% hyperbaric bupivacaine was administered at the time of induction of spinal anesthesia. Group S (n=20); 7.5 mg of 0.5% hyper- baric bupivacaine was administered intrathecally and caroverine and tiaprofenate intramuscularly at every 8 hr and 12hr postoperatively for management of postoperative pain. We evaluated the analgesic efficacy with visual analog scale (VAS), quality of sleep, and side effects.
RESULTS
VAS at 6, 12 and 24 hours after operation were significantly less (p<0.01) in the group M than in the group S. Group M was superior to group S with respect to quality of sleep (p<0.01). In the group M, the incidence of nausea was 30% (6/20) and that of pruritus was 35% (7/20) and clinical respiratory depression did not occur.
CONCLUSIONS
Intrathecal 0.25 mg morphine provides good postoperative analgesic effect. but intramuscular caroverine and tiaprofenate does not.

Keyword

Analgesia, intrathecal, morphine, intramuscular, caroverine, tiaprofenate; Surgery, transu- rethral resection of the prostate

MeSH Terms

Analgesia*
Anesthesia, Spinal
Bupivacaine
Humans
Incidence
Injections, Spinal
Morphine*
Nausea
Pain, Postoperative
Prostate*
Pruritus
Respiratory Insufficiency
Transurethral Resection of Prostate
Visual Analog Scale
Bupivacaine
Morphine