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Spinal Myoclonus Responding to Continuous Intrathecal Morphine Pump

Ahn JE, Yoo D, Jung KY, Kim JM, Jeon B, Lee MC

Spinal myoclonus is a sudden, brief, and involuntary movement of segmental or propriospinal muscle groups. Spinal myoclonus has occasionally been reported in patients undergoing opioid therapy, but the pathophysiology of...
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Integration of pain scores, morphine consumption and demand/delivery ratio to evaluate patient-controlled analgesia: the C-SIA score

Piccioni F, Doronzio A, Brambilla , Melis M, Langer M

BACKGROUND: Patient-controlled analgesia (PCA) is used to manage postoperative pain. Postoperatively, some patients need to be re-instructed on its correct use. This study explores the efficacy of re-instruction and illustrates...
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Morphine as a suspect of aiding the propagation of cancer cells

Shin Y

Controlling pain in cancer patients is important for several reasons including patient quality of life (QOL). In moderate-to-severe cancer-pain management, opioid analgesics are indispensable. Among these, morphine is the most...
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Retrospective analysis of the financial break-even point for intrathecal morphine pump use in Korea

Kim EK, Shin JY, Castañeda AM, Lee SJ, Yoon HK, Kim YC, Moon JY

BACKGROUND: The high cost of intrathecal morphine pump (ITMP) implantation may be the main obstacle to its use. Since July 2014, the Korean national health insurance (NHI) program began paying...
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Implantable drug delivery systems with morphine in fibromyalgia: A case report

Ju YM, Shin SH, Choi SC, Chon JY, Sung CH, Moon HS

The fibromyalgia syndrome (FMS) could be approached by various treatments modalities including education, aerobic exercise, cognitive behavioral therapy, tricyclic antidepressants, serotonin norepinephrine reuptake inhibitors, pregabalin, and so on. If other...
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Post-operative intravenous patient-controlled analgesic efficacy of morphine with ketorolac versus nefopam after laparoscopic gynecologic surgery: a randomized non-inferiority trial

Yoon JU, Byeon GJ, Cheon JH, Choi YM, Ri HS, Baik SW

BACKGROUND: Nefopam is a non-opioid non-steroidal centrally acting analgesic. This study was conducted to assess the analgesic efficacy of intravenous patient-controlled analgesia (IV-PCA) using nefopam alone, compared with a combination...
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STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance

Kim YJ, Kang Y, Park HY, Lee JR, Yu DY, Murata T, Gondo Y, Hwang JH, Kim YH, Lee CH, Rhee M, Han PL, Chung BH, Lee HJ, Kim KS

Striatal-enriched protein tyrosine phosphatase (STEP) is abundantly expressed in the striatum, which strongly expresses dopamine and opioid receptors and mediates the effects of many drugs of abuse. However, little is...
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Comparison of Morphine and Remifentanil on the Duration of Weaning from Mechanical Ventilation

Lee JM, Lee SH, Kwak SH, Kang HH, Lee SH, Lim JM, Jeong MA, Lee YJ, Lim CM

No abstract available.
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The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children

Lee MG, Kim HJ, Lee KH, Choi YS

BACKGROUND: Although opioids are the most commonly used medications to control postoperative pain in children, the analgesic effects could have a large inter-individual variability according to genotypes. The aim of...
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Effect of the Combination of CI-988 and Morphine on Neuropathic Pain after Spinal Cord Injury in Rats

Kim J, Kim Y, Hahm SC, Yoon YW

Cholecystokinin is known to be involved in the modulation of nociception and to reduce the efficacy of morphine analgesia. This study investigated the effects of intrathecal administration of morphine and...
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Enhancing the Enhanced Recovery Program in Colorectal Surgery - Use of Extended-Release Epidural Morphine (DepoDur(R))

Peravali R, Brock R, Bright E, Mills P, Petty D, Alberts J

PURPOSE: DepoDur(R) is a single-dose extended-release morphine injection into the epidural space. It is not commonly used, but has many advantages over traditional analgesic regimens. We analyzed a number of...
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Epidural Injection of Extended-Release Morphine During Colorectal Surgery

Kang SB

No abstract available.
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Morphine Spinal Block Anesthesia in Patients Who Undergo an Open Hemorrhoidectomy: A Prospective Analysis of Pain Control and Postoperative Complications

Moreira H, Moreira JP, Isaac RR, Alves-Neto O, Moreira TA, Vieira TH, Brasil AM

PURPOSE: This study evaluated the use of adding morphine to bupivacaine in spinal anesthesia for pain control in patients who underwent an open hemorrhoidectomy. METHODS: Forty patients were prospectively selected for...
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Spinal Block Anesthesia With Morphine in a Hemorrhoidectomy

Kim BC

No abstract available.
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Epidural Infusion of Morphine and Levobupivacaine through a Subcutaneous Port for Cancer Pain Management

Heo BH, Pyeon TH, Lee HG, Kim WM, Choi JI, Yoon MH

BACKGROUND: To manage intractable cancer pain, an alternative to systemic analgesics is neuraxial analgesia. In long-term treatment, intrathecal administration could provide a more satisfactory pain relief with lower doses of...
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Comparison of Morphine and Remifentanil on the Duration of Weaning from Mechanical Ventilation

Lee JM, Lee SH, Kwak SH, Kang HH, Lee SH, Lim JM, Jeong MA, Lee YJ, Lim CM

BACKGROUND: A randomized, multicenter, open-label, parallel group study was performed to compare the effects of remifentanil and morphine as analgesic drugs on the duration of weaning time from mechanical ventilation...
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Synergistic anti-allodynic effect between intraperitoneal thalidomide and morphine on rat spinal nerve ligation-induced neuropathic pain

Lee HG, Kim WM, Yoon MH, Park AR, Choi JI

BACKGROUND: Thalidomide has been recognized as having an anti-allodynic effect against neuropathic pain induced by spinal nerve ligation. Its clinical beneficial effects are mainly derived from its immune-modulating property, which...
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Ineffective Doses of Dexmedetomidine Potentiates the Antinociception Induced by Morphine and Fentanyl in Acute Pain Model

Unal M, Gursoy S, Altun A, Duger C, Kol IO, Kaygusuz K, Bagcivan I, Mimaroglu

The aim of this study was to evaluate the synergistic potentiation effect of ineffective doses of dexmedetomidine on antinociception induced by morphine and fentanyl in acute pain model in rats....
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Remifentanil Use in Pediatric Scoliosis Surgery-An Effective Alternative to Morphine (A Retrospective Study)

Abu-Kishk , Hod-Feins , Anekstein , Mirovsky Y, Barr J, Lahat E, Eshel G

  • KMID: 2453962
  • Yonsei Med J.
  • 2012 Sep;53(5):1014-1021.
PURPOSE: The unique properties of remifentanil make it ideal for pediatric use despite a lack of wide randomized clinical trials and fear of adverse events due to its high potency....
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The Effects of Intrathecal Adenosine A1 Receptor Agonists (R-PIA) on the Morphine Tolerance in a Rat Model of Postoperative Pain

Jun IG, Piao LZ, Kwon MY, Park JY

BACKGROUND: Analgesic tolerance to opioids has been described in both experimental and clinical conditions, which may limit their clinical utility. This study investigated the effects of intrathecal adenosine...
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