J Korean Pain Soc.
1999 May;12(1):64-69.
Effects of HP228 on Analgesia Alone or in Combination with Morphine
- Affiliations
-
- 1Pain Clinic and Department of Anesthesiology, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
Abstract
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BACKGROUND: The new drug HP22S is a cytokine restraining agent with a broad spectrum of
anti- inflammatory, analgesic, and antipyretic activity. Six healthy, adult, male volunteers
were studied to determine the independent and interactive effects of HP228 and morphine
on pain perception.
METHODS
Two groups of stimuli were applied to each volunteers before
drug administration as control, 20 min after morphine and HP228 administration, and 20 min after
combined administration of these two drugs. Two adhesive electrically-conducting pads were
applied on opposite sides of the arm approximately 8 cm apart. The electrode were connected
to an electrical impulse generator and 50 Hz 1 msec pulses of incrementally increasing intensity
were delivered at 1 sec intervals. The analgesic endpoints were the current intensity (mA) at
which the subject first detected the stimulus (THRESH), the intensity at which the stimulus was
first idenfied as being painful (PAIN), and the intensity at which the subject requested that
the stimulus be terminated due to discomfort (LIM1T). A second series of stimuli were applied
immediately thereafter using 1-sec duration 50 Hz tetanus pulses with increasing intensities
at 2-5 sec intervals.
RESULTS
There were significant differences between drug treatments (Morphine, HP228, HP228/
Morphine) and control (No drugs) in any of the measurements (PAIN, LIMIT) except THRESH with
the twitch and tetanus test. CONCLUSIONS: The data suggests that HP228 is an analgesic,
but it does not appear to interact with morphine in an additive manner.