J Korean Diabetes Assoc.  2007 Sep;31(5):421-428.

The Association between Arterial Stiffness and Albuminuria in Type 2 Diabetes

• Lee SG
• Kim YK
• Kim SR
• Ahn YS
• Kwon JH
• Kang YH
• Son SM
• Kim IJ
• Kim JS

Abstract

BACKGROUND: Brachial ankle pulse wave velocity (BaPWV) and cardio ankle vascular index (CAVI), as indicators of arterial stiffness, are increased in type 2 diabetes. Albuminuria, as a cardiovascular risk factor in type 2 diabetes, can cause endothelial dysfunction and atherosclerosis, and these can increase arterial stiffness. So we investigated the hypothesis that increased albuminuria reflects increased BaPWV and CAVI in type 2 diabetes.
METHODS
We retrospectively analyzed 106 patients (58 men and 48 women) with type 2 diabetes from March 2005 to September 2006. Urine albumin creatinine ratio (ACR) to evaluate urinary albumin excretion, BaPWV and CAVI were measured in all patients.
RESULTS
All patients were divided 3 groups, normal group (ACR < 30 mg/g Cr., n = 31), microalbuminuria group(30 < or = ACR < or = 30 mg/g Cr., n = 42), proteinuria group(ACR > 300 mg/g Cr., n = 33). BaPWV and CAVI in microalbuminuria group and proteinuria group are faster than normal group. In bivariate correlation analysis, BaPWV was not associated with ACR, but CAVI was positively correlated to ACR (r = 0.285, P = 0.003). BaPWV was positively correlated to age, diabetes duration, body mass index, systolic blood pressure, diastolic pressure, pulse pressure and negatively correlated to glomerular filtration rate (GFR). CAVI was positively correlated to age, diabetes duration and negatively correlated to GFR. In multiple linear stepwise regression analysis, BaPWV was not associated with ACR, but ACR was independent predictor for CAVI (P = 0.002).
CONCLUSION
In type 2 diabetes, albuminuria was independent predictor for indicators of arterial stiffness, especially CAVI.

Keyword

Albuminuria; Blood flow velocity; Diabetes mellitus

MeSH Terms

Albuminuria*
Ankle
Atherosclerosis
Blood Flow Velocity
Blood Pressure
Body Mass Index
Creatinine
Diabetes Mellitus
Glomerular Filtration Rate
Humans
Male
Proteinuria
Pulse Wave Analysis
Retrospective Studies
Risk Factors
Vascular Stiffness*
Creatinine

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