J Korean Child Neurol Soc.  2010 May;18(1):158-161.

A Case of Thyrotoxicosis Manifesting With Coma

  • 1Department of pediatrics, School of medicine, Jeju National University, Jeju, Korea. mickeyjin@naver.com


Thyrotoxicosis is a rare, but life-threatening condition in children. The diagnosis of Graves' thyrotoxicosis is more complicated in children than adults because associated clinical features may be atypical. Moreover, severe thyrotoxicosis may cause symptoms of CNS dysfunction, including seizures, chorea, psychosis, fluctuating confusion, and coma. We report on a case of thyrotoxicosis with coma in a 13-year-old girl. This is the first such report in the Korean pediatric population. During 2 episodes the patient presented with coma, fever without definite focus, intermittent hypertension, and sinus tachycardia. A diagnosis of Graves' thyrotoxicosis with developing thyroid storm was made. Following improvement in her condition, she was discharged on methimazole and propranolol. Thyroid dysfunction should be considered whenever unexplained coma or psychosis is encountered in children.


Thyrotoxicosis; Coma; Graves disease
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