J Korean Cancer Assoc.
1999 Aug;31(4):678-685.
Prognostic Value of PCNA , c-erbB-2 , c-fos in Patients with Non-small Cell Lung Cancer
- Affiliations
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- 1Department of Pulmonary Medicine, Ajou University School of Medicine, Korea.
- 2Department of Internal Medicine, Yonsei University College of Medicine, Korea.
- 3Department of Pathology, Yonsei University College of Medicine, Korea.
- 4Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Korea.
- 5Department of Applied Statistics, Yonsei University College of Business, Korea.
- 6Yonsei Cancer Center; Korea.
- 7Department of Pathology, Pochon Joongmun Medical College, Korea.
- 8The Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea.
Abstract
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PURPOSE: Oncogenes, tumor suppressor genes, and growth variables of tumors are important in the assessment of prognosis in lung cancer. The expression of PCNA, c-erbB-2 (HER-2/neu), and c-fos oncoprotein and their prognostic implications in surgically resected patients with non-small cell lung cancer were evaluated.
MATERIALS AND METHODS
Seventy patients with non-small cell lung cancer were included and PCNA, c-erbB-2 and c-fos overexpression were evaluated by immunohistochemical stain using paraffin-embedded tissue.
RESULTS
The mean proportion of PCNA positive cells was 18.6%, and there was no significant difference according to cell type and stage. The median survival time was significantly shorter in the group with high PCNA expression (>10%) as compared with the group with low PCNA expression (<10%) (37 months vs 16 months). Four (6.3%) of 64 cases demonstrated c-erbB-2 positivity. These were all adenocarcinoma cases. c-fos protein was only rarely overexpressed (1/51).
CONCLUSION
PCNA expression was shown to be a useful prognostic parameter in resected non-small cell lung cancer while c-erbB-2 and c-fos oncoprotein were infrequently expressed.
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