J Korean Soc Transplant.
1997 Nov;11(2):337.
Posttransplant Lymphoproliferative Disease(PTLD) following Renal Transplantation
- Affiliations
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- 1Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Korea.
- 2Department of Pathology, University of Ulsan College of Medicine and Asan Medical Center, Korea.
Abstract
- Posttransplant lymphoproliferative disease(PTLD) represents a diverse lymphoproliferative disorder ranging from non-specific reactive hyperplasia to malignant immunoblastic sarcoma developed in a setting of immunosuppression following organ or cellular transplantation. It is often associated with Epstein-Barr virus infection and high dose immunosuppression. EBV detection and immunotyping including immunoglobulin clonality is crucial for prediction of prognosis and treatment modality. We report one case of PTLD developed 5 months after renal transplantation in 33 year-old man. Clinical manifestion was submandibular mass, and EBV was detected by in situ hybridization. Histology and immunotyping revealed immunoblastic lymphoma andl lambda chain monoclonality. He has been treated with reduction of immunosuppression, acyclovir and radiotherapy, and is in stable condition with normal renal function at postoperative 11months without evidence of disease reccurrence.
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