J Korean Soc Transplant.
2000 Jun;14(1):101-108.
Four Cases of Posttransplant Lymphoproliferative Disease (PTLD) Following Renal Transplantation
- Affiliations
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- 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 2Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Abstract
- Posttransplant lymphoproliferative disorder (PTLD) is now a well-documented and serious complication of organ transplantation, ranging from polyclonal lymphoid hyperplasia to malignant lymphoma. PTLD is due to the combined effects of lymphoid proliferation induced by Epstein-Barr virus (EBV) infection, and the disruption of normal immume control by cytotoxic T cells. It is also strongly related to the potency and the cumulative doses of immunosuppressants and the type of organ transplantation. We report four cases of PTLD after renal transplantation, for whom three cases were EBV-positive by in situ hybridization.
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