J Korean Acad Rehabil Med.  2001 Oct;25(5):842-848.

Bone Metabolism in the Hemiplegic Patients after Stroke

• Kim YE
• Jung TD
• Lee KH
• Park H
• Lee YS

Abstract

OBJECTIVE
To assess change of bone metabolism in hemiplegic patients after stroke. METHOD: Sera were collected from 19 hemiplegic patients after stroke. Sera were assayed for 25-hydroxyvitamin D (25-OHD), 1,25-dihydroxyvitamin D (1,25-(OH)2D), parathyroid hormone (PTH), calcium and osteocalcin.
RESULTS
Serum 25-OHD and 1,25-(OH)2D concentration were 15.13 mg/mL and 20.88 pg/mL, respectively. Serum PTH was 47.23 pg/mL. In 5 (26%) of the patients, the serum 25-OHD concentration were < 10 ng/mL (deficient level). Ten (52%) of the patients had vitamin D concentrations between 10 and 20 ng/mL (insufficient level). The mean PTH concentration was not significantly higher in patients with deficient levels of 25-OHD (61.80 pg/mL) than those with insufficient (43.63 pg/mL) or sufficient (38.05 pg/mL) levels of 25-OHD. Serum 25-OHD concentration were lower in the late group (11.11 mg/mL) than in the early group (18.05 mg/mL), whereas serum PTH concentration were higher in the late group (58.96 pg/mL) than in the early group (38.70 pg/mL).
CONCLUSION
Compensatory hyperparathyroidism with hypovitaminosis D occurred in the hemiplgic patients after stroke, especially more than one year from onset.

Keyword

25-hydroxyvitamin D (25-OHD); Parathyroid hormone (PTH); Hemiplegia; Stroke; Bone metabolism

MeSH Terms

Calcium
Hemiplegia
Humans
Hyperparathyroidism
Metabolism*
Osteocalcin
Parathyroid Hormone
Stroke*
Vitamin D
Calcium
Osteocalcin
Parathyroid Hormone
Vitamin D