J Korean Soc Menopause.  2010 Dec;16(3):142-147.

Relationship between Metabolic Syndrome and Bone Mineral Density in Middle-aged Women

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea. kwyi@korea.ac.kr

Abstract


OBJECTIVES
To determine the relationship between metabolic syndrome (MS) and bone mineral density (BMD) in middle-aged women.
METHODS
Three hundred eight premenopausal women were included in this study, including 268 women without MS and 40 women confirmed to have MS according to the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria. Clinical markers including anthropometric parameters, the serum lipid profile, and glucose level were determined and analyzed with the BMD at the lumbar spine and femoral neck.
RESULTS
There was no significant difference in femoral neck or lumbar BMD between the controls and women with MS. In correlation tests, the body mass index (BMI) showed a significant association with the femoral (r = 0.209, P < 0.001) and lumbar BMD (r = 0.176, P = 0.002). In addition, the waist circumference (WC) was also significantly correlated with the femoral (r = 0.142, P = 0.012) and lumbar BMD (r = 0.113, P = 0.048).
CONCLUSION
The BMI and WC showed a significant positive association with the femoral and lumbar spine BMD in premenopausal women. Further studies with a large population will be needed to elucidate the combined effect of MS on BMD in middle-aged women.

Keyword

Bone mineral density; Metabolic syndrome; Middle-aged women

MeSH Terms

Biomarkers
Body Mass Index
Bone Density
Cholesterol
Female
Femur Neck
Glucose
Humans
Spine
Waist Circumference
Cholesterol
Glucose
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