Tuberc Respir Dis.  2014 Aug;77(2):60-64. 10.4046/trd.2014.77.2.60.

Clinical Aspect of MicroRNA in Lung Cancer

• Jeong HC

• KMID: 2320540
• DOI: http://doi.org/10.4046/trd.2014.77.2.60

Abstract

MicroRNAs (miRNAs) are a class of small noncoding RNAs that modulate target gene activity, and are aberrantly expressed in most types of cancer as well in lung cancer. A miRNA can potentially target a diverse set of mRNAs; further, it plays a critical role in lung tumorigenesis as well as affects patient outcome. Previous studies focused mainly on abnormal miRNAs expressions in lung cancer tissues. Interestingly, circulating miRNAs were identified in human plasma and serum in 2008. Since then, considerable effort has been directed to the study of circulating miRNAs as one of the biomarkers of lung cancer. miRNAs expression of tissues and blood in lung cancer patients is being analyzed by more researchers. Recently, to overcome the high false-positivity of low-dose chest computed tomography scan, miRNAs in lung cancer screening are being investigated. This article summarizes the recent researches regarding clinical applications of miRNAs in the diagnosis and management of lung cancer.

Keyword

MicroRNAs; Lung Neoplasms; Biological Markers

MeSH Terms

Biomarkers
Carcinogenesis
Diagnosis
Humans
Lung
Lung Neoplasms*
Mass Screening
MicroRNAs*
Plasma
RNA, Messenger
RNA, Small Untranslated
Thorax
MicroRNAs
RNA, Messenger
RNA, Small Untranslated

Figure

• 

  Figure 1 MicroRNA biogenesis and putative mechanisms release into extracellular environment. HDL: high density lipoprotein.

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