Nat Prod Sci.  2020 Dec;26(4):303-310. 10.20307/nps.2020.26.4.303.

Calyxaprenols A-D, New Merohexaprenoid Metabolites from the Marine Sponge Calyx sp.

  • 1Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA, 21702-1201


Four new merohexapenoids named calyxaprenols A-D (1 - 4), together with the known compound haliclotriol A (5), have been isolated from the marine sponge Calyx sp. which was collected from the southwest islands of Palau. Based on comprehensive spectroscopic analyses, calyxaprenols A (1) and B (2) were determined to be pentacyclic hexaprenoids that are appended to a glycolic acid-substituted phenol moiety, whereas calyxaprenols C (3) and D (4) possess a tricyclic hexaprenoid skeleton joined to a hydroquinone ring. Identification of new merohexaprenoids from a Calyx sponge expands the known taxonomic distribution of this sparsely distributed class of marine metabolites and increases the chemical diversity described for this genus of marine sponge.


Calyx sp; marine sponge; merohexaprenoid; calyxaprenol
Full Text Links
  • NPS
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: