Lab Med Online.  2012 Oct;2(4):226-231.

Mycoplasma pneumoniae Pneumonia Unresponsive to Macrolide Treatment

Affiliations
  • 1Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea. mnkim@amc.seoul.kr
  • 2Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
  • 3Department of Laboratory Medicine, The Catholic University of Korea School of Medicine, Seoul St. Mary's Hospital, Seoul, Korea.

Abstract

We present a case of community-acquired pneumonia (CAP) that developed in a previously healthy young woman. She was diagnosed with Mycoplasma pneumoniae pneumonia, but did not respond to macrolide treatment. The pathogens of CAP was examined using chest radiographs, computed tomography, and various laboratory tests including Mycoplasma IgG and IgM antibodies, blood and sputum cultures, and PCR for M. pneumoniae, Legionella pneumophila, and Chlamydophila pneumoniae. In this study, differential diagnosis of the pathogens and analysis of the mechanisms underlying their resistance to macrolide treatment were performed, and the results were discussed. After changing the antimicrobial to quinolone, the patients' clinical symptoms and radiographic findings improved, and she was discharged after 8 days.

Keyword

Community-Acquired Pneumonia; Mycoplasma pneumoniae; Macrolide; Resistance
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