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The Effectiveness of Antibiotic Macrolides Compared to Placebo for the Treatment of Pityriasis Rosea: A Systematic Review and Meta-analysis

Kim WI, Heo JY, Park T, Kim S, Cho MK

  • KMID: 2514428
  • Korean J Dermatol.
  • 2021 Mar;59(3):181-187.
Background: Pityriasis rosea is a self-limiting, acute, or subacute inflammatory skin disease that usually starts with a herald patch on the trunk and progresses to a generalized rash over the...
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Antaroide, a Novel Natural Nine-Membered Macrolide, Inhibits Melanin Biosynthesis in B16F10 Murine Melanoma Cells

Ryu MJ, Baek EK, Kim S, Seong CN, Yang I, Lim KM, Nam SJ

Abstract The demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Intensive investigation on the culture broth of Streptomyces sp. SCO-736, a marine...
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Macrolide-refractory Mycoplasma pneumoniae pneumonia and hemophagocytic lymphohistiocytosis: case report and literature review

Ma SY, Kim D, Lee J, Cho K, Suh JS, Lee SY

Mycoplasma pneumoniae causes various extra-pulmonary complications. As a rare but fatal hematological complication, hemophagocytic lymphohistiocytosis (HLH) can be observed in children with M. pneumoniae infection. We report a case of...
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Streptomyces Cytochrome P450 Enzymes and Their Roles in the Biosynthesis of Macrolide Therapeutic Agents

Cho MA, Han S, Lim YR, Kim V, Kim H, Kim D

The study of the genus Streptomyces is of particular interest because it produces a wide array of clinically important bioactive molecules. The genomic sequencing of many Streptomyces species has revealed...
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The Effect of Macrolide Therapy on Bronchopulmonary Dysplasia in Ureaplasma-Positive Very Low Birth Weight Infants

Kim S, Kim CY, Jung E, Kim H, Song WS, Lee BS, Kim EA, Kim KS

OBJECTIVE: Ureaplasma has been demonstrated the cause of short and long-term morbidities of preterm infants, especially such as bronchopulmonary dysplasia (BPD). This study aims to evaluate the influence of Ureaplasma...
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Related factors for and changes in clinical manifestations in mycoplasma pneumonia nonresponsive to macrolide treatment

Tang CL, Ryu IK, Jung JH, Park JS, Kim HB

PURPOSE: Mycoplasma pneumonia is known to be a major cause of community-acquired pneumonia in children. Macrolide has been the first-line treatment for mycoplasma pneumonia, but recently there has been an...
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Effects of Macrolide and Corticosteroid in Neutrophilic Asthma Mouse Model

An TJ, Rhee CK, Kim JH, Lee YR, Chon JY, Park CK, Yoon HK

BACKGROUND: Asthma is a disease of chronic airway inflammation with heterogeneous features. Neutrophilic asthma is corticosteroid-insensitive asthma related to absence or suppression of TH2 process and increased TH1 and/or TH17...
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Clinical Characteristics of Macrolide-Resistant Mycoplasma pneumoniae from Children in Jeju

Kim YJ, Shin KS, Lee KH, Kim YR, Choi JH

Mycoplasma pneumoniae is the major pathogen of community-acquired pneumonia in children. The prevalence of macrolide-resistant M. pneumoniae (MRMP) is important owing to the limited alternative therapies for children. We analyzed...
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Efficacy of early steroid use in Mycoplasma pneumoniae pneumonia

Kim HS, Song MG, Kim YW, Kim KS, Kim EY, Kim Y, Jang HI, Cho HM

PURPOSE: The aim of this study was to evaluate whether or not the early use of steroid is useful for treating Mycoplasma pneumoniae pneumonia. METHODS: A prospective study was conducted on...
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Macrolide Resistance and Its Impacts on M. Pneumoniae Pneumonia in Children: Comparison of Two Recent Epidemics in Korea

Kim JH, Kim JY, Yoo CH, Seo WH, Yoo Y, Song DJ, Choung JT

PURPOSE: The aim of this study was to investigate the change in macrolide resistance rate in pediatric Mycoplasma pneumoniae pneumonia and to evaluate the influence of macrolide-resistant M. pneumoniae (MRMP)...
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Mechanism of resistance acquisition and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

Yang HJ, Song DJ, Shim JY

Mycoplasma pneumoniae pneumonia (MPP) is one of the most common forms of community-acquired pneumonia in children and adolescents. Outbreaks of MPP occur in 3- to 7-year cycles worldwide; recent epidemics...
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Two patients with Mycoplasma pneumoniae pneumonia progressing to acute respiratory distress syndrome

Kwon JE, Ahn JY, Choi BS

Mycoplasma pneumoniae pneumonia is one of the most prevalent community-acquired pneumonias in pediatric patients. It commonly presents with mild respiratory symptoms and is well controlled by macrolide antibiotics. Rarely, it...
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Prevalence and clinical manifestations of macrolide resistant Mycoplasma pneumoniae pneumonia in Korean children

Lee E, Cho HJ, Hong SJ, Lee J, Sung H, Yu J

PURPOSE: Macrolide resistance rate of Mycoplasma pneumoniae has rapidly increased in children. Studies on the clinical features between macrolide susceptible-M. pneumoniae (MSMP) and macrolide resistant-M. pneumoniae (MRMP) are lacking. The...
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Is β-Lactam Plus Macrolide More Effective than β-Lactam Plus Fluoroquinolone among Patients with Severe Community-Acquired Pneumonia?: a Systemic Review and Meta-Analysis

Lee JH, Kim HJ, Kim YH

Adding either macrolide or fluoroquinolone (FQ) to β-lactam has been recommended for patients with severe community-acquired pneumonia (CAP). However, due to the limited evidence available, there is a question as...
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Expression and Regulation of Transcription Factor FoxA2 in Chronic Rhinosinusitis With and Without Nasal Polyps

Luo Q, Zhang J, Wang H, Chen F, Luo X, Miao B, Wu X, Ma R, Luo X, Xu G, Shi J, Li H

PURPOSE: Chronic rhinosinusitis (CRS) is characterized by the excessive production of mucus. However, the molecular mechanism underlying mucin overproduction in CRS with or without nasal polyps (CRSwNP and CRSsNP, respectively)...
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Effect of Prenatal and Postnatal Prophylaxis with Macrolide for Ureaplasma on the Development of Bronchopulmonary Dysplasia in Preterm Infants

Jung E, Kim S, Jung YH, Lee J, Shin SH, Choi CW, Kim EK, Kim HS, Kim BI, Choi JH

PURPOSE: We aimed to evaluate the effects of two different macrolide prophylaxis protocols (prenatal and postnatal) for Ureaplasma on the development of bronchopulmonary dysplasia (BPD). METHODS: We retrospectively reviewed the medical...
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Macrolide Resistance of Mycoplasma pneumoniae and Its Detection Rate by Real-Time PCR in Primary and Tertiary Care Hospitals

Uh Y, Hong JH, Oh KJ, Cho HM, Park SD, Kim J, Yoon KJ

BACKGROUND: This study aimed to evaluate the prevalence of Mycoplasma pneumoniae in primary and tertiary care hospitals and its macrolide resistance rate. METHODS: Nasopharyngeal swabs were collected from 195 pediatric patients...
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Two Cases of Mycoplasma pneumoniae Pneumonia with A2063G Mutation in the 23S rRNA Gene in Siblings

Hong JH, Chun JK, Uh Y, Oh KJ, Kim J, Yoon KJ

We describe 2 cases of pneumonia caused by the same macrolide-resistant Mycoplasma pneumoniae in siblings. M. pneumoniae was identified using real-time PCR. Direct sequence analysis of the 23S rRNA gene...
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Mycoplasma pneumoniae Pneumonia Unresponsive to Macrolide Treatment

Ji M, Sung H, Shim TS, Jang W, Kim MN

  • KMID: 2312211
  • Lab Med Online.
  • 2012 Oct;2(4):226-231.
We present a case of community-acquired pneumonia (CAP) that developed in a previously healthy young woman. She was diagnosed with Mycoplasma pneumoniae pneumonia, but did not respond to macrolide treatment....
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Clinical and Epidemiologic Characteristics of Mycoplasma pneumoniae Pneumonia in Adults During 2011 Epidemic

Seo YB, Yang TU, Kim IS, Hong KW, Song JY, Cheong HJ, Kim WJ

BACKGROUND: Recent data regarding the clinical epidemiologic characteristics of Mycoplasma pneumoniae pneumonia in Korean adults are insufficient. This study was conducted in order to compare epidemics in different ages and...
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