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Relationship of Heart Rate Variability with Triglyceride-Glucose Index among Korean Men and Women in a Primary Care Clinic

Ryu HE, Lee SB, Jung DH, Park B

Background: Reduced heart rate variability (HRV) can be a predictor of all causes of death. Few studies have analyzed the association between HRV and the triglyceride-glucose (TyG) index in a...
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Associations between Serum Ferritin and Triglyceride Glucose Index: Using Health Examination Data at One Medical Institution’s Health Examination Center (2020)

Lee JI, Joe H, Cho YJ, Shin HS, Hong SH, Yoo BW, Oh JE, Shin KS, Son DY

Background: The overload of iron in the body is known to cause oxidative stress and inflammatory damage to cell and tissues, leading to diabetes mellitus. The relationship between serum ferritin,...
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From Barbells to Brawns: The Physiology of Resistance Exercise and Skeletal Muscle Growth

Park J, Mcllvain V, Rosenberg J, Donovan L, Desai P, Kim JY

A complex network of biochemical pathways carries out the process of muscle regeneration/growth following resistance exercise. The initial inflammatory response following muscle damage is primarily mediated by the nuclear factor...
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Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells

Park D, Lee JH, Yoon SP

Benzimidazole anthelmintic agents have been recently repurposed to overcome cancers resistant to conventional therapies. To evaluate the anti-cancer effects of benzimidazole on resistant cells, various cell death pathways were investigated...
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Body fat distribution and insulin resistance among Korean middle-aged women: a Korean National Health and Nutrition Examination Survey

Lee SM, Ryu KJ, Son S, Lee YJ, Park H, Kim T

Objective To evaluate menopause-related changes in body fat distribution and their relationship with insulin resistance in middleaged Korean women. Methods We analyzed women aged 40-60 years using data from the National Health and...
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Bismuth-Based Quadruple Therapy versus MetronidazoleIntensified Triple Therapy as a First-Line Treatment for Clarithromycin-Resistant Helicobacter pylori Infection: A Multicenter Randomized Controlled Trial

Seo SI, Lim H, Bang CS, Yang YJ, Baik GH, Lee SP, Jang HJ, Kae SH, Kim J, Kim HY, Shin WG

Background/Aims: Clarithromycin resistance is a main factor for treatment failure in the context of Helicobacter pylori infection. However, the treatment regimen for clarithromycin-resistant H. pylori infection has not yet been determined....
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Changes of Causative Organism and Antimicrobial Resistance in Urinary Tract Infections After the COVID-19

Choi YH, Tae JH, Lee MK, Kim TH

Purpose: During the coronavirus disease 2019 (COVID-19) pandemic, several studies reported changes in the distribution of microorganisms that cause major legal, respiratory, and gastrointestinal infectious diseases and increases in the...
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The effects of Allomyrina dichotoma larval extract on palmitate-induced insulin resistance in skeletal muscle cells

Kim K, Sim MS, Kwak MK, Jang SE, Oh YS

Purpose: Allomyrina dichotoma larvae are one of the approved edible insects with nutritional value and various functional and medicinal properties. Previously we have demonstrated that the Allomyrina dichotoma ...
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Implementation of antimicrobial stewardship programs

Kwon KT

Background: The antimicrobial stewardship program (ASP) is a coordinated intervention designed to improve and measure the appropriate antibiotics use by selecting an optimal antibiotic drug regimen, including dosing, therapy duration,...
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Antibiotics for multidrug-resistant gram-negative bacteria

Kang CI

Background: Increase in antimicrobial-resistant bacteria continues to be challenge to physicians. Particularly, multidrug-resistant (MDR) gram-negative bacilli (GNB), such as extended-spectrum beta-lactamase (ESBL)-producers and carbapenem-resistant pathogens, are becoming a major human...
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Antibiotics for multidrug-resistant gram-positive bacteria

Song KH

Background: Antimicrobial resistance is a major global threat to public health and is associated with increased morbidity and mortality. A few therapeutic options for the treatment of multidrug resistant (MDR)...
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Current status of multidrug-resistant bacteria

Kim D, Jeong SH

Background: The dissemination of multidrug-resistant (MDR) pathogen is of major public health concern as it leads to increased mortality rate, length of hospital stays, and medical expenses. Current Concepts: Korean Government...
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Multidrug-resistant bacteria: a national challenge requiring urgent addressal

Kim NJ

Background: Multidrug-resistant bacterial infections are a worldwide threat owing to their increased prevalence, and poor prognosis due to inadequate antibacterial drugs. Current Concepts: Until 2019, several new antibacterial agents, targeting gram-positive...
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High Levels of Hyaluronic Acid Synthase-2 Mediate NRF2-Driven Chemoresistance in Breast Cancer Cells

Choi BH, Ryoo I, Sim KH, Ahn Hj, Lee YJ, Kwak MK

Hyaluronic acid (HA), a ligand of CD44, accumulates in some types of tumors and is responsible for tumor progression. The nuclear factor erythroid 2-like 2 (NRF2) regulates cytoprotective genes and...
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High-on-Aspirin Platelet Reactivity Differs Between Recurrent Ischemic Stroke Associated With Extracranial and Intracranial Atherosclerosis

Noh KC, Choi Hy, Woo HG, Chang JY, Heo SH, Chang Di, Kim BJ

Background and Purpose Ischemic stroke recurs despite the use of antiplatelet agents. Various mechanisms are involved in recurrence due to intracranial atherosclerosis (ICAS) and extracranial atherosclerosis (ECAS). High-on-aspirin platelet reactivity...
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Susceptibility of β-Lactam Antibiotics and Genetic Mutation of Drug-Resistant Mycobacterium tuberculosis Isolates in Korea

Park S, Jung J, Kim J, Han SB, Ryoo S

Background Mycobacterium tuberculosis (Mtb) is resistant to the β-lactam antibiotics due to a non-classical transpeptidase in the cell wall with β-lactamase activity. A recent study showed that meropenem combined with...
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Epidemiological characteristics of carbapenemresistant Enterobacteriaceae and carbapenem-resistant Acinetobacter baumannii in a tertiary referral hospital in Korea

Kang S, Jeong IS

Objectives This study aimed to identify the epidemiological characteristics of patients with carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii (CRE/CRAB) isolates in a tertiary referral hospital in Korea. Methods We collected and analyzed...
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Acute Disseminated Pneumococcal Infection with Meningitis and Septic Arthritis Caused by Extensively Drug-resistant Streptococcus pneumoniae

Shi HJ, Baek JY, Chung DR, Kim K, Peck KR, Kang CI

The emergence and spread of antimicrobial resistance threatens the successful treatment of invasive pneumococcal disease (IPD). We report a case of disseminated pneumococcal infection with meningitis, spondylitis, and septic arthritis...
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Microorganisms Isolated from Urine Cultures and Their Antimicrobial Susceptibility Patterns at a Commercial Laboratory during 2018-2020

Kwak B, Hong J, Bae HG, Park YS, Lee MK, Lee K, Lee KR

Background: Antimicrobial resistance of bacterial pathogens that cause urinary tract infections is a leading concern in Korea. This study analyzed the urine culture results and antimicrobial susceptibility trend in different...
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Detection and Control of Candida auris in Healthcare Settings

Kwon YJ, Shin JH

Since it was first reported in 2009 after isolation from ear cultures of 1 Japanese patient and 15 Korean patients, Candida auris infections have been reported in at least 35...
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